Molecular Neurobiology

, Volume 36, Issue 1, pp 113–128

Cannabinoids in Eating Disorders and Obesity

Authors

    • Psychiatric UnitFundación Hospital Alcorcón
Article

DOI: 10.1007/s12035-007-0018-x

Cite this article as:
Arias Horcajadas, F. Mol Neurobiol (2007) 36: 113. doi:10.1007/s12035-007-0018-x

Abstract

Cannabinoid system is a crucial mechanism in regulating food intake and energy metabolism. It is involved in central and peripheral mechanisms regulating such behavior, interacting with many other signaling systems with a role in metabolic regulation. Cannabinoid agonists promote food intake, and soon a cannabinoid antagonist, rimonabant, will be marketed for the treatment of obesity. It not only causes weight loss, but also alleviates metabolic syndrome. We present a review of current knowledge on this subject, along with data from our own research: genetic studies on this system in eating disorders and obesity and studies locating cannabinoid receptors in areas related to food intake. Such studies suggest cannabinoid hyperactivity in obesity, and this excessive activity may have prognostic implications.

Keywords

Cannabinoid systemObesityEating disordersFood intakeEnergy metabolism

Abbreviations

AgRP

agouti-related protein

AEA

anandamide

2-AG

2-arachidonoyl-glycerol

ARC

arcuate hypothalamic nucleus

BBB

blood–brain barrier

BMI

body mass index

BDNF

brain-derived neurotrophic factor

CB1

cannabinoid receptor type 1

CCK

cholecystokinin

CART

cocaine- and amphetamine-regulated transcript

CRH

corticotropin-releasing hormone

DIO

diet-induced obesity

DMH

dorsomedial hypothalamic nucleus

ED

eating disorders

ECS

endocannabinoid system

FAAH

fatty-acid amide hydrolase

FAS

fatty-acid synthase

GHS-R

ghrelin receptor

GAPDH

glyceraldehyde-3-phosphate dehydrogenase

HDL

high-density lipoprotein

HPA

hypothalamic–pituitary–adrenal axis

KO

knockout

LHN

lateral hypothalamic nucleus

MAP-kinase

mitogen-activated protein kinase

MCH

melanine concentrating hormone

α-MSH

melanocyte stimulating hormone

NPY

neuropeptide Y

Nac

nucleus accumbens

NTS

nucleus of the tractus solitarius

OEA

oleoyl-ethanolamide

PVN

paraventricular nucleus

PYY

peptide YY

POMC

pro-opiomelanocortin

RIO

Rimonabant in Obesity clinical trials

SREBP-1c

sterol response element-binding protein 1c

STRATUS

Studies with Rimonabant and Tobacco Use

THC

tetrahydrocannabinol

TRH

thyrotropin-releasing hormone

VTA

ventral tegmental area

VMH

ventromedial hypothalamic nucleus

Copyright information

© Humana Press Inc. 2007