Molecular Neurobiology

, Volume 36, Issue 1, pp 60–67

Cannabinoids and Gliomas

Authors

  • Guillermo Velasco
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
  • Arkaitz Carracedo
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
  • Cristina Blázquez
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
  • Mar Lorente
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
  • Tania Aguado
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
  • Amador Haro
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
  • Cristina Sánchez
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
  • Ismael Galve-Roperh
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
    • Department of Biochemistry and Molecular Biology I, School of BiologyComplutense University
Article

DOI: 10.1007/s12035-007-0002-5

Cite this article as:
Velasco, G., Carracedo, A., Blázquez, C. et al. Mol Neurobiol (2007) 36: 60. doi:10.1007/s12035-007-0002-5

Abstract

Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances—the endocannabinoids—that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor cells, including glioma cells, in laboratory animals. They do so by modulating key cell signaling pathways, mostly the endoplasmic reticulum stress response, thereby inducing antitumoral actions such as the apoptotic death of tumor cells and the inhibition of tumor angiogenesis. Of interest, cannabinoids seem to be selective antitumoral compounds, as they kill glioma cells, but not their non-transformed astroglial counterparts. On the basis of these preclinical findings, a pilot clinical study of Δ9-tetrahydrocannabinol (THC) in patients with recurrent glioblastoma multiforme has been recently run. The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids.

Keywords

Cannabinoid Receptor Glioma Cancer Apoptosis Angiogenesis Experimental therapeutics Clinical trial

Copyright information

© Humana Press Inc. 2007