Medical Oncology

, 32:59

Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma

  • Tianxiang Ge
  • Qiujin Shen
  • Ning Wang
  • Yurong Zhang
  • Zhouhong Ge
  • Wei Chu
  • Xiufang Lv
  • Fengbo Zhao
  • Weifeng Zhao
  • Jia Fan
  • Wenxin Qin
Original Paper

DOI: 10.1007/s12032-014-0367-z

Cite this article as:
Ge, T., Shen, Q., Wang, N. et al. Med Oncol (2015) 32: 59. doi:10.1007/s12032-014-0367-z

Abstract

The timely diagnosis and effective treatment are essential for improving the survival and prognosis of hepatocellular carcinoma (HCC) patients. Alpha-fetoprotein (AFP) is the most widely used biomarker for diagnosis of HCC, but the low sensitivity and specificity limits its clinical application. In this study, we evaluated the diagnostic capability of the combination of AFP with two novel potential biomarkers, dickkopf-1 (DKK1) and osteopontin (OPN), for HCC in 390 participants including 89 patients with HCC, 36 patients with liver cirrhosis, 65 patients with chronic hepatitis B, and 200 health controls. We found the combination of all three markers as a panel showed a better diagnostic performance than that of AFP alone, with increased AUC [0.948 (95 % CI 0.921–0.968) vs. 0.831 (95 % CI 0.790–0.867)] and sensitivity (88.76 vs. 71.91 %). Moreover, this combination showed a great improvement in diagnosing early-stage HCC patients. In conclusion, the combined use of AFP, DKK1, and OPN as a biomarker panel could enhance the diagnostic ability for HCC.

Keywords

Hepatocellular carcinoma Alpha-fetoprotein Dickkopf-1 Osteopontin Diagnosis 

Abbreviations

AFP

Alpha-fetoprotein

DKK1

Dickkopf-1

OPN

Osteopontin

HCC

Hepatocellular carcinoma

LC

Liver cirrhosis

CHB

Chronic hepatitis B

HC

Health control

ROC

Curve receiver operating characteristic curve

AUC

Area under ROC curve

CI

Confidence interval

PPV

Positive predictive value

NPV

Negative predictive value

LR

Likelihood ratio

Supplementary material

12032_2014_367_MOESM1_ESM.doc (62 kb)
Supplementary material 1 (DOC 61 kb)

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Tianxiang Ge
    • 1
    • 2
  • Qiujin Shen
    • 2
  • Ning Wang
    • 2
  • Yurong Zhang
    • 2
  • Zhouhong Ge
    • 2
  • Wei Chu
    • 2
  • Xiufang Lv
    • 3
  • Fengbo Zhao
    • 3
  • Weifeng Zhao
    • 4
  • Jia Fan
    • 5
  • Wenxin Qin
    • 2
  1. 1.Shanghai Medical College of Fudan UniversityShanghaiChina
  2. 2.State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina
  3. 3.Medical College of Nantong UniversityNantongChina
  4. 4.Department of Infectious DiseasesFirst Affiliated Hospital of Soochow UniversitySuzhouChina
  5. 5.Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of EducationFudan UniversityShanghaiChina

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