Vitamin D receptor gene polymorphisms and esophageal cancer risk in a Chinese population: a negative study
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Vitamin D receptor (VDR) gene polymorphisms have been reported to influence susceptibility to some malignant cancers. However, there were few published findings on the association between VDR polymorphisms and esophageal cancer susceptibility. Our investigation was aimed to obtain a precise estimation of the association between VDR polymorphisms and esophageal cancer susceptibility. We conducted a hospital-based case–control study to evaluate the genetic effects of functional single-nucleotide polymorphisms VDR rs2107301 T>C, rs2228570 C>T, rs1989969 C>T and rs11568820 G>A on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were enrolled for this study. The genotypes were determined using ligation detection reaction method. There were no significant associations between the four VDR variants and ESCC risk. Stratified analyses indicated a significantly increased risk of ESCC associated with VDR rs2107301 T>C polymorphism among patients who were drinking. These findings demonstrated that the risk of ESCC associated with VDR rs2107301 T>C polymorphism may be modified by lifestyle factors such as drinking. However, the results should be validated in larger well-designed studies in future.
- Chen Y, Liu W, Sun T, et al. 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Immunol. 2013;190:3687–95. CrossRef
- Fu B, Wang H, Wang J, et al. Epigenetic regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA methylation and histone modification. PLoS One. 2013;8:e61423. CrossRef
- Walters MR. Newly identified actions of the vitamin D endocrine system. Endocrinol Rev. 1992;13:1–46. CrossRef
- Baker AR, McDonnell DP, Hughes M, et al. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci USA. 1988;85:3294–8. CrossRef
- Thomas MG, Tebbutt S, Williamson RC. Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line. Gut. 1992;33:1660–3. CrossRef
- Jurutka PW, Whitfield GK, Hsieh JC, et al. Molecular nature of the vitamin D receptor and its role in regulation of gene expression. Rev Endocr Metab Disord. 2001;2:203–16. CrossRef
- Uitterlinden AG, Fang Y, Meurs JBV, et al. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004;338:143–56. CrossRef
- Boscoe FP, Schymura MJ. Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002. BMC Cancer. 2006;6:264. CrossRef
- Grant WB. An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer Epidemiol Biomarkers Prev. 2002;94:1867–75.
- Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006;98:451–9. CrossRef
- Chen W, Dawsey SM, Qiao YL, et al. Prospective study of serum 25(OH)-vitamin D concentration and risk of esophageal and gastric cancer. Br J Cancer. 2007;97:123–8. CrossRef
- Abnet CC, Chen W, Dawsey SM, et al. Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia. Cancer Epidemiol Biomarkers Prev. 2007;16:1889–93. CrossRef
- Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta. 2006;371:1–12. CrossRef
- Chen ZJ, Zhao H, He L, et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2011;43:55. CrossRef
- Kostner K, Denzer N, Muller CS, et al. The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res. 2009;29:3511–36.
- Galina L, Wilkens LR, Pamela J, et al. Vitamin D receptor gene polymorphisms and epithelial ovarian cancer risk cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:2566–71. CrossRef
- Qin X, Lu Y, Qin AP, et al. Vitamin D receptor Bsm I polymorphism and ovarian cancer risk a meta-analysis. Int J Gynecol Cancer. 2013;23:1178–83. CrossRef
- Gapska P, Scott RJ, Serrano-Fernandez P, et al. Vitamin D receptor variants and the malignant melanoma risk: a population-based study. Cancer Epidemiol. 2009;33:103–7. CrossRef
- Dogan I, Onen HI, Yurdakul AS, et al. Polymorphisms in the Vitamin D receptor gene and risk of lung cancer. Med Sci Monit. 2009;15:B232–42.
- Xiong L, Cheng J, Gao JY, et al. Vitamin D receptor genetic variants are associated with chemotherapy response and prognosis in patients with advanced non-small-cell lung cancer. Clin Lung Cancer. 2013;14:433–9.
- Chen TC, Kittaka A. Novel vitamin D analogs for prostate cancer therapy. ISRN Urol. 2011;2011:301490.
- Raimondi S, Johansson H, Maisonneuve P, et al. Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis. 2009;30:1170–80. CrossRef
- Chang CK, Mulholland HG, Cantwell MM, et al. Vitamin D receptor gene variants and esophageal adenocarcinoma risk: a population-based case–control study. J Gastrointest Cancer. 2012;43:512–7.
- Holick CN, Stanford JL, Kwon EM, et al. Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:1990–9. CrossRef
- Ruggiero M, Pacini S, Aterini S, et al. Vitamin D receptor gene polymorphisms associated with metastatic breast cancer. Oncol Res. 1998;10:43–6.
- Lundin AC, Soderkvist P, Eriksson B, et al. Association of breast cancer progression with a vitamin D receptor gene polymorphism. South-East Sweden Breast Cancer Group. Cancer Res. 1999;59:2332–4.
- Vitamin D receptor gene polymorphisms and esophageal cancer risk in a Chinese population: a negative study
- Online Date
- January 2014
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Esophageal cancer
- Molecular epidemiology
- Industry Sectors
- Author Affiliations
- 1. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, 8 Dianli Rd, Zhenjiang, 212002, China
- 2. Department of Cardiothoracic Surgery, The First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University, Changzhou, 213003, China
- 3. Cancer Institute, Department of Chemotherapy, People’s Hospital Affiliated to Jiangsu University, Zhenjiang, 212002, Jiangsu, China
- 4. Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People’s Hospital, Changzhou, 213003, China