Medical Oncology

, 31:827

Vitamin D receptor gene polymorphisms and esophageal cancer risk in a Chinese population: a negative study

Authors

  • Haiyong Gu
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Xu Wang
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Liang Zheng
    • Department of Cardiothoracic SurgeryThe First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University
  • Weifeng Tang
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Changqing Dong
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Liming Wang
    • Cancer Institute, Department of ChemotherapyPeople’s Hospital Affiliated to Jiangsu University
  • Yijun Shi
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Aizhong Shao
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Guowen Ding
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Chao Liu
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
  • Ruiping Liu
    • Department of OrthopedicsAffiliated Hospital of Nanjing Medical University, Changzhou Second People’s Hospital
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
    • Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu University
Original Paper

DOI: 10.1007/s12032-013-0827-x

Cite this article as:
Gu, H., Wang, X., Zheng, L. et al. Med Oncol (2014) 31: 827. doi:10.1007/s12032-013-0827-x

Abstract

Vitamin D receptor (VDR) gene polymorphisms have been reported to influence susceptibility to some malignant cancers. However, there were few published findings on the association between VDR polymorphisms and esophageal cancer susceptibility. Our investigation was aimed to obtain a precise estimation of the association between VDR polymorphisms and esophageal cancer susceptibility. We conducted a hospital-based case–control study to evaluate the genetic effects of functional single-nucleotide polymorphisms VDR rs2107301 T>C, rs2228570 C>T, rs1989969 C>T and rs11568820 G>A on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were enrolled for this study. The genotypes were determined using ligation detection reaction method. There were no significant associations between the four VDR variants and ESCC risk. Stratified analyses indicated a significantly increased risk of ESCC associated with VDR rs2107301 T>C polymorphism among patients who were drinking. These findings demonstrated that the risk of ESCC associated with VDR rs2107301 T>C polymorphism may be modified by lifestyle factors such as drinking. However, the results should be validated in larger well-designed studies in future.

Keywords

VDRPolymorphismsEsophageal cancerMolecular epidemiology

Abbreviations

VDR

Vitamin D receptor

LD

Linkage disequilibrium

OR

Odds ratio

CI

Confidential interval

SNPs

Single-nucleotide polymorphisms

ESCC

Esophageal squamous cell carcinoma

Copyright information

© Springer Science+Business Media New York 2013