Medical Oncology

, 30:664

Feasibility and efficacy of combined cisplatin plus irinotecan chemotherapy for gastroenteropancreatic neuroendocrine carcinomas

  • Z. H. Lu
  • J. Li
  • M. Lu
  • X. T. Zhang
  • J. Li
  • J. Zhou
  • X. C. Wang
  • J. F. Gong
  • J. Gao
  • Y. Li
  • L. Shen
Original Paper

DOI: 10.1007/s12032-013-0664-y

Cite this article as:
Lu, Z.H., Li, J., Lu, M. et al. Med Oncol (2013) 30: 664. doi:10.1007/s12032-013-0664-y

Abstract

No standard treatment is currently available for gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC). Therefore, we conducted this study to evaluate the effect of the combination of irinotecan and cisplatin in the treatment of GEP-NECs. Clinical data of 16 locally advanced or metastatic GEP-NEC patients treated with irinotecan plus cisplatin regimen in our center from September 2009 to August 2011 were reviewed. The regimen included 2-week cycles of 180 mg/m2 irinotecan and 50 mg/m2 cisplatin on day 1. Median age was 57 years. The overall response rate was 57.1 %, with a disease control rate of 78.6 %. One patient achieved pathologic complete response and underwent esophagectomy after chemotherapy. Two patients who had gotten progressive disease were given sequential octreotide long-acting release (LAR) treatment and got disease progression again within 1 month. Six patients who achieved disease control received octreotide LAR as maintenance treatment. The total number of cycles of octreotide was 41, with a median of 4.5 (3–20 cycles). The progression-free survival was 5.5 months, with overall survival of 10.6 months. Grades 3–4 hematological adverse events (AEs) occurred in 10 patients (62.5 %) and 3 patients (18.7 %) suffered grades 3–4 non-hematological AEs; no patient died of AEs. The irinotecan plus cisplatin chemotherapy is moderately effective and tolerable well tolerated in advanced or metastatic GEP-NEC patients; octreotide LAR may be a good maintenance treatment and should be considered as a treatment option for these patients in the future.

Keywords

Gastroenteropancreatic neuroendocrine carcinomaOctreotideChemotherapyOverall survival

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Z. H. Lu
    • 1
  • J. Li
    • 1
  • M. Lu
    • 1
  • X. T. Zhang
    • 1
  • J. Li
    • 1
  • J. Zhou
    • 1
  • X. C. Wang
    • 1
  • J. F. Gong
    • 1
  • J. Gao
    • 1
  • Y. Li
    • 1
  • L. Shen
    • 1
  1. 1.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI OncologyPeking University School of Oncology, Beijing Cancer Hospital and InstituteBeijingChina