Medical Oncology

, 30:604

UGT1A1*6/*28 polymorphisms could predict irinotecan-induced severe neutropenia not diarrhea in Chinese colorectal cancer patients

  • Jing Gao
  • Jun Zhou
  • Yanyan Li
  • Ming Lu
  • Ru Jia
  • Lin Shen
Original Paper

DOI: 10.1007/s12032-013-0604-x

Cite this article as:
Gao, J., Zhou, J., Li, Y. et al. Med Oncol (2013) 30: 604. doi:10.1007/s12032-013-0604-x

Abstract

The aim of this study was to investigate the associations between UDP-glucuronosyltransferase (UGT) 1A1 polymorphisms and irinotecan-induced toxicities in Chinese advanced colorectal cancer patients. The genotypes of UGT1A1*6 and UGT1A1*28 were analyzed by PCR amplification and Sanger sequencing in 276 advanced colorectal cancer patients receiving irinotecan-containing chemotherapy. The influences of UGT1A1*6/*28 polymorphisms on severe diarrhea and neutropenia were analyzed. The overall incidence of UGT1A1*6 and UGT1A1*28 variants was 35.5 % (GA: 28.6 %; AA: 6.9 %) and 21.0 % (TA6/TA7: 19.9 %; TA7/TA7: 1.1 %) in our cohort, respectively. A total of 16 patients (5.8 %, 16/276) had severe diarrhea and 56 patients (20.3 %, 56/276) had severe neutropenia. Neither UGT1A1*6 nor UGT1A1*28 variants were associated with severe diarrhea; however, either UGT1A1*6 (P = 0.001) or UGT1A1*28 (P = 0.029) variants were significantly associated with severe neutropenia. No differences were found between severe toxicities and clinical response in this study. Compared to western countries, Chinese patients had a distinct frequency of UGT1A1*6 or UGT1A1*28 genotypes. Both UGT1A1*6 and UGT1A1*28 variants were closely associated with irinotecan-induced severe neutropenia, but not diarrhea.

Keywords

UGT1A1PolymorphismIrinotecanDiarrheaNeutropenia

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jing Gao
    • 1
  • Jun Zhou
    • 1
  • Yanyan Li
    • 1
  • Ming Lu
    • 1
  • Ru Jia
    • 1
  • Lin Shen
    • 1
  1. 1.Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)Peking University, Cancer Hospital & InstituteBeijingChina