Medical Oncology

, 30:588

Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer

  • Xiaosong Ge
  • Yuanbin Chen
  • Xiaoyu Liao
  • Deqing Liu
  • Fangfang Li
  • Honglian Ruan
  • Weihua Jia
Original Paper

DOI: 10.1007/s12032-013-0588-6

Cite this article as:
Ge, X., Chen, Y., Liao, X. et al. Med Oncol (2013) 30: 588. doi:10.1007/s12032-013-0588-6

Abstract

Long noncoding RNAs (lncRNA) are emerging as key molecules in human cancer. Prostate cancer–associated ncRNA transcripts 1 (PCAT-1), a lncRNA, has been recently revealed involving in human prostate cancer progression. However, whether PCAT-1 could serve as novel biomarker to predict prognosis in colorectal cancer (CRC) or not is unknown. We therefore carried out the present study to explore the correlation between PCAT-1 expression and the progression of CRC. In this study, the expression of PCAT-1 in 108 cases of CRC tissues and matched 81 adjacent normal tissues were determined by quantitative real-time PCR. Furthermore, the copy number variation of PCAT-1 was also measured in 17 tumor tissues and matched normal tissues. Our results showed that PCAT-1 expression in CRC tissues was significantly upregulated compared with the matched normal tissues (p < 0.001) and the overexpression of PCAT-1(upregulated by more than 50 %) was found in 64 % (62/81) of CRC. Moreover, PCAT-1 gene copy number variation explains only a few percent of observed overexpression. In addition, there was a significant association between PCAT-1 expression and distant metastasis (p = 0.04), but not other clinical characteristics. More important, CRC patients with PCAT-1 higher expression have shown significantly poorer overall survival than those with lower PCAT-1 expression (p < 0.001). Also, multivariable Cox regression analysis identified PCAT-1 overexpression as an independent prognostic factor for CRC (p = 0.007, HR = 3.12 95 %CI = 1.355–7.185). In conclusion, our results suggest that high expression of PCAT-1 is involved in CRC progression and could be a novel biomarker of poor prognosis in patient with colorectal cancer.

Keywords

PCAT-1Long noncoding RNAColorectal cancer

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Xiaosong Ge
    • 1
  • Yuanbin Chen
    • 1
  • Xiaoyu Liao
    • 1
  • Deqing Liu
    • 1
  • Fangfang Li
    • 1
  • Honglian Ruan
    • 2
  • Weihua Jia
    • 1
  1. 1.State Key Laboratory of Oncology in South ChinaSun Yat-Sen University Cancer CenterGuangzhouChina
  2. 2.School of Public HealthSun Yat-Sen UniversityGuangzhouChina