Medical Oncology

, 30:433

Liposomal amphotericin B and surgery as successful therapy for pulmonary Lichtheimia corymbifera zygomycosis in a pediatric patient with acute promyelocytic leukemia on antifungal prophylaxis with posaconazole

  • Grazina Kleinotiene
  • Gintas Posiunas
  • Juozas Raistenskis
  • Edvardas Zurauskas
  • Sigita Stankeviciene
  • Valentina Daugelaviciene
  • Maciej Machaczka
Short Communication

DOI: 10.1007/s12032-012-0433-3

Cite this article as:
Kleinotiene, G., Posiunas, G., Raistenskis, J. et al. Med Oncol (2013) 30: 433. doi:10.1007/s12032-012-0433-3
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Abstract

Pulmonary zygomycosis, also referred to as mucormycosis, is a fungal infection of lungs caused by fungi of the order Mucorales in the class of Zygomycetes. It is usually associated with high morbidity and mortality. Here, we report the case of a 14-year-old girl with pediatric acute promyelocytic leukemia (APL) on antifungal prophylaxis with posaconazole, who developed pulmonary Lichtheimia corymbifera (formerly Absidia corymbifera) zygomycosis. She was successfully treated by means of liposomal amphotericin B (L-AmB) and surgery. To our knowledge, this is the first published report on pediatric APL and pulmonary zygomycosis in the English language literature. At present, the patient is in complete remission of her APL and without any signs of recurrence of zygomycosis. This report suggests that efficient diagnostics, increased physician awareness, and reliance on adjunctive surgical therapy can result in a favorable outcome of pulmonary zygomycosis in immunocompromised children with hematological malignancies.

Keywords

Acute promyelocytic leukemiaChildrenLichtheimia corymbiferaInvasive fungal infectionPediatricTreatmentZygomycosis

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Grazina Kleinotiene
    • 1
  • Gintas Posiunas
    • 2
  • Juozas Raistenskis
    • 3
    • 4
  • Edvardas Zurauskas
    • 5
    • 6
  • Sigita Stankeviciene
    • 1
  • Valentina Daugelaviciene
    • 1
  • Maciej Machaczka
    • 7
  1. 1.Centre of Hematology and Oncology, Children’s HospitalVilnius University Hospital Santariskiu ClinicsVilniusLithuania
  2. 2.Clinic of Pediatric Surgery, Children’s HospitalVilnius University Hospital Santariskiu ClinicsVilniusLithuania
  3. 3.Department of Rehabilitation, Physical and Sports Medicine, Faculty of MedicineVilnius UniversityVilniusLithuania
  4. 4.Children’s HospitalVilnius University Hospital Santariskiu ClinicsVilniusLithuania
  5. 5.Lithuanian National Centre of PathologyVilnius University Hospital Santariskiu ClinicsVilniusLithuania
  6. 6.Department of Pathology, Forensic Medicine and Pharmacology, Faculty of MedicineVilnius UniversityVilniusLithuania
  7. 7.Division of Hematology, Department of Medicine at Huddinge, Karolinska Institutet, and Hematology Center KarolinskaKarolinska University Hospital HuddingeStockholmSweden