Medical Oncology

, Volume 29, Issue 4, pp 2824–2830

PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

  • Sayaka Yuzawa
  • Mitsunobu R. Kano
  • Takahiro Einama
  • Hiroshi Nishihara
Original Paper

DOI: 10.1007/s12032-012-0193-0

Cite this article as:
Yuzawa, S., Kano, M.R., Einama, T. et al. Med Oncol (2012) 29: 2824. doi:10.1007/s12032-012-0193-0

Abstract

Pancreatic adenocarcinoma is a lethal disease that often develops a desmoplastic reaction in tumor stroma. In general, desmoplasia is thought to promote tumor growth. However, its molecular pathology and prognostic potential have not been fully investigated. Here, we investigate 26 cases of pancreatic ductal adenocarcinoma and examine the clinicopathological association between survival and expression levels of several molecular markers for stromal cells. These include alpha-smooth muscle actin (SMA) and platelet-derived growth factor (PDGF) receptor β (PDGFRβ). Both are markers of activated fibroblasts or pancreatic stellate cells (PSCs) that play an important role in desmoplasia. The staining patterns of both molecular markers were not uniform, so we categorized them into 3 grades (high, middle, and low) according to intensity. Interestingly, Kaplan–Meier analysis revealed that higher expression of PDGFRβ matched shorter prognosis (p = 0.0287, log-rank test) as well as lymphatic invasion and lymph node metastasis, whereas SMA did not (p = 0.6122). Our results suggest the prognostic potential of cancer stroma via PDGF-B signaling. Regulation of PDGF-B-associated signaling crosstalk between cancer cells and stroma cells, therefore, may indicate a possible therapeutic target for desmoplastic malignant tumors such as pancreatic adenocarcinoma.

Keywords

Pancreatic adenocarcinomaTumor stromaPrognosisPDGFRβSMA

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Sayaka Yuzawa
    • 1
  • Mitsunobu R. Kano
    • 2
  • Takahiro Einama
    • 3
  • Hiroshi Nishihara
    • 1
  1. 1.Department of Translational Pathology, Graduate School of MedicineHokkaido UniversityHokkaidoJapan
  2. 2.Medical Scientist Training Program, Faculty of MedicineUniversity of TokyoTokyoJapan
  3. 3.Division of Gastroenterological and General Surgery, Department of SurgeryAsahikawa Medical CollegeHokkaidoJapan