Medical Oncology

, Volume 29, Issue 2, pp 682–685

Association between Gly1619ARG polymorphism of IGF2R domain 11 (rs629849) and advanced stage of oral cancer

  • Angela J. Yoon
  • Athanasios I. Zavras
  • Mu-Kuan Chen
  • Chiao-Wen Lin
  • Shun-Fa Yang
Original Paper

DOI: 10.1007/s12032-011-9863-6

Cite this article as:
Yoon, A.J., Zavras, A.I., Chen, M. et al. Med Oncol (2012) 29: 682. doi:10.1007/s12032-011-9863-6

Abstract

Insulin-like growth factor II receptor (IGF2R) degrades mitogen and hence is associated with tumor suppressor function. The aim of this study was to assess whether genetic variation in the mitogen-binding domain of IGF2R, Gly1619Arg, disrupts normal function of IGF2R and contributes to further progression and distant metastasis of localized oral squamous cell carcinoma (OSCC). Gly1619Arg polymorphism of IGF2R domain 11 (rs629849) was assessed in blood samples of 113 individuals with histology-confirmed OSCC, and IGF2R genotypes were correlated with the stage of tumor (localized; TMN stages I–II versus advanced; TMN stages III–IV). After controlling for demographic covariates and known risk factors for oral cancer, such as tobacco, alcohol, and areca nut use, threefold increased risk of advanced stage of OSCC was noted in those subjects who had one or two copies of the IGF2R-A-allele when compared with the GG genotype. In contrast, when compared with the carriers of the A-allele, the GG genotype demonstrated to be protective against advanced disease (adjusted odds ratios of 0.32). IGF2R genetic polymorphism may be associated with decreased function of IGF2 receptor there by contributing to the advancement and distant metastasis of localized oral cancer.

Keywords

Gly1619Arg polymorphismInsulin-like growth factor II receptor (IGF2R)Oral squamous cell carcinomaMetastasis

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Angela J. Yoon
    • 1
  • Athanasios I. Zavras
    • 2
  • Mu-Kuan Chen
    • 3
    • 4
  • Chiao-Wen Lin
    • 5
  • Shun-Fa Yang
    • 3
    • 6
  1. 1.Division of Oral and Maxillofacial PathologyColumbia University College of Dental MedicineNew YorkUSA
  2. 2.Division of Oral Epidemiology and BiostatisticsColumbia University College of Dental MedicineNew YorkUSA
  3. 3.Institute of MedicineChung Shan Medical UniversityTaichungTaiwan
  4. 4.Department of Otorhinolaryngology-Head and Neck SurgeryChanghua Christian HospitalChanghuaTaiwan
  5. 5.Institute of Biochemistry and BiotechnologyChung Shan Medical UniversityTaichungTaiwan
  6. 6.Department of Medical ResearchChung Shan Medical University HospitalTaichungTaiwan