Medical Oncology

, Volume 28, Issue 4, pp 1589–1595

Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement

Authors

    • Cytogenetic LaboratoryMSCM Cancer Centre and Institute
  • Grzegorz Rymkiewicz
    • Flow Cytometry LaboratoryMSCM Cancer Centre and Institute
  • Beata Grygalewicz
    • Cytogenetic LaboratoryMSCM Cancer Centre and Institute
  • Renata Woroniecka
    • Cytogenetic LaboratoryMSCM Cancer Centre and Institute
  • Paulina Krawczyk
    • Cytogenetic LaboratoryMSCM Cancer Centre and Institute
  • Katarzyna Czyz-Domanska
    • Department of Lymphoprolipherative DiseaseMSCM Cancer Centre and Institute
  • Jan Walewski
    • Department of Lymphoprolipherative DiseaseMSCM Cancer Centre and Institute
Original Paper

DOI: 10.1007/s12032-010-9614-0

Cite this article as:
Pienkowska-Grela, B., Rymkiewicz, G., Grygalewicz, B. et al. Med Oncol (2011) 28: 1589. doi:10.1007/s12032-010-9614-0

Abstract

Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma characterized by specific morphological and immunophenotypic features. The basic genetic feature of BL is the rearrangement of MYC gene, visible as t(8;14)(q24;q32) translocation or its variant. However, some lymphomas with characteristic BL morphology are nowadays diagnosed as B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL (Inter-DLBCL/BL) for biological or clinical reasons. We present four lymphomas without the MYC rearrangement presented typical Burkitt morphology, FCM immunophenotype with some deviations when compared to a typical BL. The cases were finally diagnosed as Inter-DLBCL/BL. All of them presented a recurrent abnormality within the chromosome 11: dup(11)(q23q13). We suppose that the dup(11)(q23q13), in absence of the MYC gene rearrangement, is connected with borderline lymphomas with a morphology similar or identical to that of the Burkitt lymphoma. Identifying such an aberration may be helpful in the diagnostics of Inter-DLBCL/BL eventually forming a distinct subgroup of lymphomas.

Keywords

Non-Hodgkin’s lymphomaBurkitt morphologyChromosome aberrationsFISH

Copyright information

© Springer Science+Business Media, LLC 2010