Medical Oncology

, Volume 28, Issue 3, pp 822–828

Standard chemotherapy is superior to high-dose chemotherapy with autologous stem cell transplantation on overall survival as the first-line therapy for patients with aggressive non-Hodgkin lymphoma: a meta-analysis

  • Jing Wang
  • Ping Zhan
  • Jian Ouyang
  • Bing Chen
  • Rongfu Zhou
  • Yonggong Yang
Original Paper

DOI: 10.1007/s12032-010-9517-0

Cite this article as:
Wang, J., Zhan, P., Ouyang, J. et al. Med Oncol (2011) 28: 822. doi:10.1007/s12032-010-9517-0

Abstract

Randomized controlled trials (RCTs) have reported conflicting results on the impact of high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HDCT) as the first-line treatment for patients with aggressive non-Hodgkin lymphoma (NHL). We performed a systematic meta-analysis to assess the efficacy of HDCT compared to conventional chemotherapy in patients with aggressive NHL with regard to overall survival (OS) at 3 years. We gathered the data for our analysis from MEDLINE, EMBASE, Cochrane controlled trials register, Cochrane Library, and Science Citation Index (1/1990 to 11/2008) searches. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the random effect model. Fourteen RCTs were identified that were published in full text and included a total of 2,413 patients. There was evidence that HDCT showed decreased OS (HR 1.20, 95% CI 1.05–1.37, P = 0.006) at 3 years when compared with conventional chemotherapy. The variation in OS probabilities between studies was not statistically significant (test for heterogeneity, Q = 10.14, df = 13, P = 0.683). Thus, our meta-analysis showed that HDCT in aggressive non-Hodgkin lymphoma had decreased overall survival outcome compared with conventional chemotherapy.

Keywords

High-dose chemotherapy Autologous stem cell transplantation Non-Hodgkin’s lymphoma Meta-analysis 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jing Wang
    • 1
  • Ping Zhan
    • 2
  • Jian Ouyang
    • 1
  • Bing Chen
    • 1
  • Rongfu Zhou
    • 1
  • Yonggong Yang
    • 1
  1. 1.Department of HematologyThe Affiliated DrumTower Hospital of Nanjing University Medical SchoolNanjingPeople’s Republic of China
  2. 2.Department of Respiratory MedicineNanjing Chest HospitalNanjingPeople’s Republic of China