Original Paper

Medical Oncology

, Volume 27, Issue 4, pp 1114-1118

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

  • Jie YangAffiliated withDepartment of Nephrology, Tangdu Hospital
  • , Yunxin CaoAffiliated withDepartment of Immunology, The Fourth Military Medical University
  • , Jifeng SunAffiliated withDepartment of Nephrology, Tangdu Hospital Email author 
  • , Yong ZhangAffiliated withDepartment of Immunology, The Fourth Military Medical University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases. It has shown to have anti-carcinogenic properties and is known to prevent tumor development in some cancers. In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells. Silencing miR-15a and miR-16 by specific inhibitors restored the expression of Bcl-2. Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells.

Keywords

Curcumin miR-15a miR-16 Breast cancer Bcl-2