Medical Oncology

, 25:462

Primary T-cell lymphoma of the thyroid: case report and review of the literature

CASE

DOI: 10.1007/s12032-008-9059-x

Cite this article as:
Yang, H., Li, J. & Shen, T. Med Oncol (2008) 25: 462. doi:10.1007/s12032-008-9059-x

Abstract

Here we report a rare case of primary T-cell lymphoma of the thyroid gland. A 32-year-old Chinese man was admitted to our hospital because of marked goiter and subcutaneous nodules. Computed tomography (CT) scan of the neck disclosed diffuse enlargement of the thyroid gland. A diagnosis of peripheral T-cell lymphoma was made according to cytopathological findings of fine-needle aspiration (FNA) of the thyroid gland and skin biopsy. Immunohistochemistry stain showed that the tumor was positive for CD3 and negative for CD20. Clonal T-cell receptor (TCR-γ) gene rearrangements were demonstrated by polymerase chain reaction. After six cycles of combination chemotherapy (bleomycin, cyclophosphamide, doxorubicin, vincristine, and prednisone), the thyroid retracted to normal size gradually.

Keywords

Thyroid lymphomaT-cell

Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  1. 1.Department of Endocrinology and MetabolismPeking Union Medical College HospitalBeijingP.R. China
  2. 2.Department of HematologyPeking Union Medical College HospitalBeijingP.R. China