Article

Journal of Molecular Neuroscience

, Volume 48, Issue 3, pp 654-659

Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis

  • Samira FargaliAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Masato SadahiroAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Cheng JiangAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Amy L. FrickAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Tricia IndallAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Valeria CoglianiAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Jelle WelagenAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Wei-Jye LinAffiliated withFishberg Department of Neuroscience, Mount Sinai School of Medicine
  • , Stephen R. SaltonAffiliated withFishberg Department of Neuroscience, Mount Sinai School of MedicineBrookdale Department of Geriatrics and Palliative Medicine, Mount Sinai School of MedicineFriedman Brain Institute, Mount Sinai School of MedicineDepartment of Neuroscience, Mount Sinai School of Medicine Email author 

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Abstract

Members of the neurotrophin family, including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5, and other neurotrophic growth factors such as ciliary neurotrophic factor and artemin, regulate peripheral and central nervous system development and function. A subset of the neurotrophin-dependent pathways in the hypothalamus, brainstem, and spinal cord, and those that project via the sympathetic nervous system to peripheral metabolic tissues including brown and white adipose tissue, muscle and liver, regulate feeding, energy storage, and energy expenditure. We briefly review the role that neurotrophic growth factors play in energy balance, as regulators of neuronal survival and differentiation, neurogenesis, and circuit formation and function, and as inducers of critical gene products that control energy homeostasis.

Keywords

Brain-derived neurotrophic factor (BDNF) Corticotropin-releasing hormone (CRH) Hypothalamus Nerve growth factor (NGF) Neurotrophin VGF