, Volume 45, Issue 3, pp 690-695
Date: 08 Jul 2011

Immunotherapy for Tauopathies

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Abstract

Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach. Studies pioneered by our laboratory and confirmed by others have shown that both active and passive immunizations targeting disease-related tau epitopes successfully reduce tau aggregates in vivo and slow or prevent behavioral impairments in mouse models of tauopathy. Here, we summarize recent advances in this new field.

Journal of Molecular Neuroscience - (Special Issue on 7th International Conference on Frontotemporal Dementias), in press, 2011. Guest Editor: Bernardino Ghetti, Editor-in-Chief: Illana Gozes