Article

Journal of Molecular Neuroscience

, Volume 44, Issue 1, pp 59-67

First online:

Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF

  • Nina Leão Marques ValenteAffiliated withDepartamento de Psiquiatria, Universidade Federal de São Paulo Email author 
  • , Homero ValladaAffiliated withDepartamento de Psiquiatria e LIM-23, da Faculdade de Medicina da Universidade de São Paulo
  • , Quirino CordeiroAffiliated withDepartamento de Psiquiatria e LIM-23, da Faculdade de Medicina da Universidade de São Paulo
  • , Karen MiguitaAffiliated withDepartamento de Psiquiatria e LIM-23, da Faculdade de Medicina da Universidade de São PauloInstituto Adolfo Lutz
  • , Rodrigo Affonseca BressanAffiliated withDepartamento de Psiquiatria, Universidade Federal de São Paulo
  • , Sergio Baxter AndreoliAffiliated withDepartamento de Psiquiatria, Universidade Federal de São Paulo
  • , Jair Jesus MariAffiliated withDepartamento de Psiquiatria, Universidade Federal de São PauloHealth Service and Population Research Department, Institute of Psychiatry, King’s College London
  • , Marcelo Feijó MelloAffiliated withDepartamento de Psiquiatria, Universidade Federal de São Paulo

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Abstract

Posttraumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder marked by behavioral and physiologic alterations which commonly follows a chronic course. Exposure to a traumatic event constitutes a necessary, but not sufficient, factor. There is evidence from twin studies supporting a significant genetic predisposition to PTSD. However, the precise genetic loci still remain unclear. The objective of the present study was to identify, in a case–control study, whether the brain-derived neurotrophic factor (BDNF) val66met polymorphism (rs6265), the dopamine transporter (DAT1) three prime untranslated region (3′UTR) variable number of tandem repeats (VNTR), and the serotonin transporter (5-HTTPRL) short/long variants are associated with the development of PTSD in a group of victims of urban violence. All polymorphisms were genotyped in 65 PTSD patients as well as in 34 victims of violence without PTSD and in a community control group (n = 335). We did not find a statistical significant difference between the BDNF val66met and 5-HTTPRL polymorphism and the traumatic phenotype. However, a statistical association was found between DAT1 3′UTR VNTR nine repeats and PTSD (OR = 1.82; 95% CI, 1.20–2.76). This preliminary result confirms previous reports supporting a susceptibility role for allele 9 and PTSD.

Keywords

Polymorphism DAT1 BDNF 5-HTTLPR Posttraumatic stress disorder PTSD Violence