Journal of Molecular Neuroscience

, Volume 44, Issue 3, pp 152–158

Progesterone Enhances Transthyretin Expression in the Rat Choroid Plexus In Vitro and In Vivo via Progesterone Receptor

  • Telma Quintela
  • Isabel Gonçalves
  • Ana Martinho
  • Celso Henrique Alves
  • Maria João Saraiva
  • Pedro Rocha
  • Cecília Reis Alves Santos
Article

DOI: 10.1007/s12031-010-9398-x

Cite this article as:
Quintela, T., Gonçalves, I., Martinho, A. et al. J Mol Neurosci (2011) 44: 152. doi:10.1007/s12031-010-9398-x

Abstract

Depletion of ovarian hormones 17β-estradiol (E2) and progesterone (P) after menopause may contribute to the decline in cognitive performance and increases the risk of Alzheimer’s disease (AD) in women, striking the importance of understanding the regulation of pivotal proteins involved in AD pathogenesis by ovarian hormones. Transthyretin (TTR) is now recognized as one of such proteins due to its ability to sequester and degrade amyloid β (Aβ) into less harmful peptides and preventing their aggregation. We have previously demonstrated that E2 enhances TTR expression. In this study, we investigate the effects of P on TTR expression in primary cultures of rat choroid plexus epithelial cells and in adult ovariectomized female rats. The results obtained demonstrate that, in vitro and in vivo, TTR is up-regulated by P. In addition, the mechanism underlying the response of TTR to P was investigated, and we provide evidence that this response is achieved through a progesterone receptor-mediated mechanism. Our results reinforce the importance of ovarian hormones on the regulation of TTR, which may reflect on the processing of Aβ peptides and consequently on AD onset and progression.

Keywords

Cerebrospinal fluidChoroid plexusEstradiolProgesteroneProgesterone receptorTransthyretin

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Telma Quintela
    • 1
  • Isabel Gonçalves
    • 1
  • Ana Martinho
    • 1
  • Celso Henrique Alves
    • 1
  • Maria João Saraiva
    • 2
  • Pedro Rocha
    • 3
  • Cecília Reis Alves Santos
    • 1
    • 4
  1. 1.Health Sciences Research Centre—CICSUniversity of Beira InteriorCovilhãPortugal
  2. 2.Molecular Neurobiology, Institute of Molecular and Cellular Biology—IBMC, Porto and ICBASUniversity of PortoPortoPortugal
  3. 3.Chemistry DepartmentUniversity of Beira InteriorCovilhãPortugal
  4. 4.Centre of Investigation in Health Sciences—CICSUniversity of Beira InteriorCovilhãPortugal