Journal of Molecular Neuroscience

, Volume 41, Issue 1, pp 110–113

Coenzyme Q10 Reduces β-Amyloid Plaque in an APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease

Authors

  • Xifei Yang
    • Hong Kong Applied Science and Technology Research Institute Company Limited
    • Department of Pathophysiology, Tongji Medical CollegeHuazhong University of Science and Technology
  • George Dai
    • Athinoula A. Martinos Center of Biomedical Imaging, Department of RadiologyMassachusetts General Hospital
    • Hong Kong Applied Science and Technology Research Institute Company Limited
  • Edward S. Yang
    • Hong Kong Applied Science and Technology Research Institute Company Limited
Article

DOI: 10.1007/s12031-009-9297-1

Cite this article as:
Yang, X., Dai, G., Li, G. et al. J Mol Neurosci (2010) 41: 110. doi:10.1007/s12031-009-9297-1

Abstract

We previously reported that coenzyme Q10 (CoQ10) could reduce intracellular deposition in an aged transgenic mouse model. Here, we further tested the effect of CoQ10 on amyloid plaque in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer’s disease (AD). By using immunohistochemistry and magnetic resonance imaging to determine the burden of amyloid plaque, we found that oral administration of CoQ10 can efficiently reduce the burden of the plaques in this mouse model. These data demonstrate that in addition to reducing intracellular deposition of Aβ, CoQ10 can also reduce plaque pathology. Our study further supports the use of CoQ10 as a therapeutic candidate for AD.

Keywords

Alzheimer’s diseaseCoenzyme Q10PlaqueMR imaging

Copyright information

© Humana Press 2009