Journal of Molecular Neuroscience

, Volume 39, Issue 1, pp 125–136

Role of Central Calcitonin Gene-Related Peptide (CGRP) in Locomotor and Anxiety- and Depression-Like Behaviors in Two Mouse Strains Exhibiting a CGRP-Dependent Difference in Thermal Pain Sensitivity

  • Ara Schorscher-Petcu
  • Jean-Sébastien Austin
  • Jeffrey S. Mogil
  • Rémi Quirion
Article

DOI: 10.1007/s12031-009-9201-z

Cite this article as:
Schorscher-Petcu, A., Austin, JS., Mogil, J.S. et al. J Mol Neurosci (2009) 39: 125. doi:10.1007/s12031-009-9201-z

Abstract

We have previously shown that, in AKR and C57BL/6 mice, a genetic polymorphism results in differential expression of the peptide, calcitonin gene-related polypeptide (CGRP), explaining a strain difference in thermal pain sensitivity. Although CGRP is widely distributed in the brain, little is known about the effects of supraspinal CGRP. We used AKR and C57BL/6 mice as a model to explore the effects of centrally (intracerebroventricular) injected CGRP and the CGRP receptor antagonists, CGRP8–37 and BIBN4096BS, in a series of behavioral assays. Locomotor activity was significantly increased in C57BL/6 mice following the injection of BIBN4096BS and in both strains after the administration of CGRP8–37 into the third ventricle. CGRP increased paw-withdrawal latencies in C57BL/6 mice only, while decreasing depression-like behaviors in both strains in the forced-swimming test. CGRP and CGRP receptor antagonists failed to modulate activity in the elevated plus maze, a model of anxiety. Taken together, these results suggest a complex role for supraspinal CGRP systems in the regulation of locomotion, nociception, and depression-like behaviors.

Keywords

CGRP Supraspinal Depression Anxiety Thermal pain sensitivity Locomotion 

Copyright information

© Humana Press 2009

Authors and Affiliations

  • Ara Schorscher-Petcu
    • 1
    • 2
  • Jean-Sébastien Austin
    • 3
  • Jeffrey S. Mogil
    • 3
  • Rémi Quirion
    • 1
    • 2
    • 4
  1. 1.Department of Neurology and NeurosurgeryMcGill UniversityMontrealCanada
  2. 2.Douglas Mental Health University Institute, Institute of Neuroscience, Mental Health and AddictionMcGill UniversityMontréalCanada
  3. 3.Department of Psychology and Center for Research on PainMcGill UniversityMontrealCanada
  4. 4.Department of PsychiatryMcGill UniversityMontrealCanada

Personalised recommendations