Brief Communication

Journal of Gastrointestinal Cancer

, Volume 44, Issue 1, pp 115-117

First online:

Pregnancy with Metastatic Gastrointestinal Stromal Tumor (GIST) on Imatinib Chemotherapy: an Oncologist’s Nightmare and Obstetrician’s Dilemma

  • Neerja GoelAffiliated withDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital
  • , Ria MalikAffiliated withDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital Email author 
  • , Balkesh RathiAffiliated withDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital
  • , Sruthi BhaskaranAffiliated withDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital
  • , Shalini RajaramAffiliated withDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital
  • , Sumita MehtaAffiliated withDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital
  • , Nitin AgarwalAffiliated withDepartment of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital

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Abstract

Introduction

Gastrointestinal stromal tumors (GISTs) are among the few cancers amenable to successful treatment by targeted molecular therapy with KIT receptor inhibitors like imatinib mesylate. Increasing incidence of this tumor and its successful treatment has given rise to issues of fertility and child bearing in patients affected at young age. Although contraception advice and termination of early pregnancy have been the standard practice in patients on such therapy, an occasional patient who desires pregnancy can leave both obstetrician and oncologist perplexed.

Clinical Presentation

We report our experience in a rare patient of metastatic GIST who had a successful normal pregnancy while on imatinib therapy. We further attempt to evaluate similar evidence in literature.

Keywords

Metastatic gastrointestinal stromal tumor Pregnancy Imatinib Cancer chemotherapy