, Volume 43, Issue 1 Supplement, pp 156-160
Date: 15 May 2012

Management of Esophageal Squamous Cell Carcinoma with Definitive Chemoradiotherapy in a Patient with Scleroderma: Case Report and Review of the Literature

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Scleroderma is a disease characterized by fibrosis of the skin and internal organs, and is associated with changes in microvasculature. The association of scleroderma with malignancy has been debated, with early cohort studies showing no increase in the incidence of cancer among patients with scleroderma [1, 2]. Subsequent studies showed an increased incidence of lung cancer, breast cancer, esophageal cancer, oropharyngeal cancer, non-melanoma skin cancer, and lymphoproliferative malignancies in patients with scleroderma [29].

Both adenocarcinoma and squamous cell carcinoma of the esophagus have been described as occurring with increased incidence in patients with scleroderma [10]. Patients with scleroderma are thought to have increased incidence of gastric reflux, development of Barrett’s esophagus, and subsequent development of esophageal adenocarcinoma, though this has not yet been validated in a prospective manner [1113]. Overall, patients with scleroderma have a standar ...


Written informed consent was obtained from the patient for publication of the case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.