Journal of Gastrointestinal Cancer

, Volume 42, Issue 3, pp 165–170

Gastrointestinal Cancer Educational Case Series: Management of Metastatic Adenocarcinoma of Unknown Primary Origin in a Ph+ ALL Survivor

  • Celina Ang
  • Eileen M. O’Reilly
  • Ghassan K. Abou-Alfa
  • Ali Shamseddine
  • Hadi Skouri
  • Ayman Tawil
  • Mohamad A. Eloubeidi
  • Maeve Lowery
  • Mohamed Kharfan-Dabaja
  • Tania Kaprealian
  • Sally Temraz
  • Hassan Sibai
  • Hassan Farran
  • Manish A. Shah
MGMT. OF COMPLEX CASES IN GI ONCOLOGY

DOI: 10.1007/s12029-010-9233-1

Cite this article as:
Ang, C., O’Reilly, E.M., Abou-Alfa, G.K. et al. J Gastrointest Canc (2011) 42: 165. doi:10.1007/s12029-010-9233-1
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Abstract

Introduction

Secondary malignancies and chronic end-organ sequelae are significant and steadily rising consequences of cancer therapy. The workup and management of a carcinoma of unknown primary must consider the patient’s clinical presentation, radiologic and pathologic findings, and comorbidities.

Case Report

We present the case of a 50-year-old female survivor of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with significant treatment-related end-organ sequelae who developed a metastatic adenocarcinoma of unknown primary 15 years following curative therapy for her ALL. The complex management issues related to the investigations and choice of therapy for this patient are reviewed.

Discussion

This case discusses key issues related to the workup and management of a carcinoma of unknown primary. In addition, it illustrates the importance of taking patient comorbidities into consideration and tailoring investigations and therapy accordingly.

Keywords

Carcinoma of unknown primary managementCarcinoma of unknown primary investigationsSecondary malignanciesCancer therapy-induced cardiotoxicity

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Celina Ang
    • 1
  • Eileen M. O’Reilly
    • 1
    • 3
  • Ghassan K. Abou-Alfa
    • 1
  • Ali Shamseddine
    • 2
  • Hadi Skouri
    • 2
  • Ayman Tawil
    • 2
  • Mohamad A. Eloubeidi
    • 2
  • Maeve Lowery
    • 1
  • Mohamed Kharfan-Dabaja
    • 2
  • Tania Kaprealian
    • 2
  • Sally Temraz
    • 2
  • Hassan Sibai
    • 2
  • Hassan Farran
    • 2
  • Manish A. Shah
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.American University of BeirutBeirutLebanon
  3. 3.Department of Medicine, Gastrointestinal Oncology ServiceMemorial Sloan-Kettering Cancer CenterNew YorkUSA