Neurocritical Care

, Volume 21, Issue 3, pp 551–559

The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage

  • Blessing N. R. Jaja
  • Daniel Attalla
  • R. Loch Macdonald
  • Tom A. Schweizer
  • Michael D. Cusimano
  • Nima Etminan
  • Daniel Hanggi
  • David Hasan
  • S. Claiborne Johnston
  • Peter Le Roux
  • Benjamin Lo
  • Ada Louffat-Olivares
  • Stephan Mayer
  • Andrew Molyneux
  • Adam Noble
  • Audrey Quinn
  • Thomas Schenk
  • Julian Spears
  • Jeffrey Singh
  • Michael Todd
  • James Torner
  • Ming Tseng
  • William van den Bergh
  • Mervyn D. I. Vergouwen
  • George K. C. Wong
Review Article

DOI: 10.1007/s12028-014-9990-y

Cite this article as:
Jaja, B.N.R., Attalla, D., Macdonald, R.L. et al. Neurocrit Care (2014) 21: 551. doi:10.1007/s12028-014-9990-y

Abstract

Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.

Keywords

Subarachnoid hemorrhage Clinical trials Database Cerebrovascular disease Intracranial aneurysm Stroke 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Blessing N. R. Jaja
    • 1
  • Daniel Attalla
    • 1
  • R. Loch Macdonald
    • 1
  • Tom A. Schweizer
    • 1
  • Michael D. Cusimano
    • 1
  • Nima Etminan
    • 2
  • Daniel Hanggi
    • 2
  • David Hasan
    • 3
  • S. Claiborne Johnston
    • 4
  • Peter Le Roux
    • 5
  • Benjamin Lo
    • 1
  • Ada Louffat-Olivares
    • 1
  • Stephan Mayer
    • 6
  • Andrew Molyneux
    • 7
  • Adam Noble
    • 8
  • Audrey Quinn
    • 9
  • Thomas Schenk
    • 10
  • Julian Spears
    • 1
  • Jeffrey Singh
    • 11
  • Michael Todd
    • 3
  • James Torner
    • 3
  • Ming Tseng
    • 12
  • William van den Bergh
    • 13
  • Mervyn D. I. Vergouwen
    • 14
  • George K. C. Wong
    • 15
  1. 1.Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael’s HospitalUniversity of TorontoTorontoCanada
  2. 2.Department of NeurosurgeryMedical Faculty Heinrich Heine UniversityDüsseldorfGermany
  3. 3.University of IowaIowa CityUSA
  4. 4.University of California San FranciscoSan FranciscoUSA
  5. 5.Jefferson UniversityPhiladelphiaUSA
  6. 6.Columbia UniversityNew YorkUSA
  7. 7.Oxford UniversityOxfordUK
  8. 8.Kings College LondonLondonUK
  9. 9.The General InfirmaryLeedsUK
  10. 10.Friedrich-Alexander UniversityErlangenGermany
  11. 11.University of TorontoUniversity Health NetworkTorontoCanada
  12. 12.Medicines and Healthcare Products Regulatory AgencyLondonUK
  13. 13.University Medical Center GroningenGroningenThe Netherlands
  14. 14.University Medical Center UtrechtUtrechtThe Netherlands
  15. 15.Chinese University of Hong KongHong KongChina

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