Cardiac Rupture After Intravenous t-PA Administration in Acute Ischemic Stroke
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Ventricular free wall rupture is a fatal complication of myocardial infarction (MI). Although described in MI patients who receive thrombolytic therapy, this complication is not well known in ischemic stroke patients who receive intravenous (IV) t-PA.
We present a 93-year-old woman with an acute onset of a right middle cerebral artery syndrome in the setting of subacute MI. IV t-PA was administered and she subsequently developed asystolic arrest and died. Autopsy showed subacute MI, hemopericardium, and rupture of the left ventricle.
This case illustrates a fatal cardiac complication of IV thrombolytic therapy for stroke. The speculated mechanism is hemorrhage into the infarcted myocardium.
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- Cardiac Rupture After Intravenous t-PA Administration in Acute Ischemic Stroke
Volume 13, Issue 2 , pp 261-262
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- Humana Press Inc
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- Ischemic stroke
- Myocardial infarction
- IV t-PA
- Cardiac rupture
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- Author Affiliations
- 1. Department of Neurology, University of California San Francisco, 505 Parnassus Avenue, Box 0114, San Francisco, CA, 94143-0114, USA
- 2. Neuropathology Unit, University of California San Francisco, San Francisco, CA, USA