Neurocritical Care

, 11:288

Feasibility of NIRS in the Neurointensive Care Unit: A Pilot Study in Stroke Using Physiological Oscillations

  • Susanne Muehlschlegel
  • J. Selb
  • M. Patel
  • S. G. Diamond
  • M. A. Franceschini
  • A. G. Sorensen
  • D. A. Boas
  • L. H. Schwamm
Original Article

DOI: 10.1007/s12028-009-9254-4

Cite this article as:
Muehlschlegel, S., Selb, J., Patel, M. et al. Neurocrit Care (2009) 11: 288. doi:10.1007/s12028-009-9254-4

Abstract

Introduction

Near-infrared spectroscopy (NIRS) is a non-invasive, real-time bedside modality sensitive to changes in cerebral perfusion and oxygenation and is highly sensitive to physiological oscillations at different frequencies. However, the clinical feasibility of NIRS remains limited, partly due to concerns regarding NIRS signal quantification, which relies on mostly arbitrary assumptions on hemoglobin concentrations and tissue layers. In this pilot study comparing stroke patients to healthy controls, we explored the utility of the interhemispheric correlation coefficient (IHCC) during physiological oscillations in detecting asymmetry in hemispheric microvascular hemodynamics.

Methods

Using bi-hemispheric continuous-wave NIRS, 12 patients with hemispheric strokes and 9 controls were measured prospectively. NIRS signal was band-pass filtered to isolate cardiac (0.7–3 Hz) and respiratory (0.15–0.7 Hz) oscillations. IHCCs were calculated in both oscillation frequency bands. Using Fisher’s Z-transform for non-Gaussian distributions, the IHCC during cardiac and respiratory oscillations were compared between both groups.

Results

Nine patients and nine controls had data of sufficient quality to be included in the analysis. The IHCCs during cardiac and respiratory oscillations were significantly different between patients versus controls (cardiac 0.79 ± 0.18 vs. 0.94 ± 0.07, P = 0.025; respiratory 0.24 ± 0.28 vs. 0.59 ± 0.3; P = 0.016).

Conclusions

Computing the IHCC during physiological cardiac and respiratory oscillations may be a new NIRS analysis technique to quantify asymmetric microvascular hemodynamics in stroke patients in the neurocritical care unit. It allows each subject to serve as their own control obviating the need for arbitrary assumptions on absolute hemoglobin concentration. Future clinical applications may include rapid identification of patients with ischemic brain injury in the pre-hospital setting. This promising new analysis technique warrants further validation.

Keywords

Near-infrared spectroscopyCerebrovascular diseaseStrokeCritical care

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Susanne Muehlschlegel
    • 1
  • J. Selb
    • 2
  • M. Patel
    • 2
  • S. G. Diamond
    • 3
  • M. A. Franceschini
    • 2
  • A. G. Sorensen
    • 2
    • 4
  • D. A. Boas
    • 2
  • L. H. Schwamm
    • 5
  1. 1.Neurocritical Care Service, Departments of Neurology, Anesthesia/Critical Care and SurgeryUMASS Memorial Medical Center, University of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Athinoula Martinos Center for Biomedical ImagingMassachusetts General Hospital, Harvard UniversityCharlestownUSA
  3. 3.Thayer School of EngineeringDartmouth CollegeHanoverUSA
  4. 4.Department of RadiologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  5. 5.Stroke Service, Department of NeurologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA