Neurocritical Care

, Volume 12, Issue 1, pp 62–68

Subjecting Acute Ischemic Stroke Patients to Continuous Tube Feeding and an Intensive Computerized Protocol Establishes Tight Glycemic Control

  • N. D. Kruyt
  • G. J. Biessels
  • T. M. Vriesendorp
  • J. H. DeVries
  • J. B. L. Hoekstra
  • P. W. Elbers
  • L. J. Kappelle
  • P. Portegies
  • M. Vermeulen
  • Y. B. W. E. M. Roos
Original Article

DOI: 10.1007/s12028-009-9230-z

Cite this article as:
Kruyt, N.D., Biessels, G.J., Vriesendorp, T.M. et al. Neurocrit Care (2010) 12: 62. doi:10.1007/s12028-009-9230-z

Abstract

Introduction

Tight glycemic control (TGC) after ischemic stroke may improve clinical outcome but previous studies failed to establish TGC, principally because of postprandial glucose surges. The aim of the present study was to investigate if safe, effective and feasible TGC can be achieved with continuous tube feeding and a computerized treatment protocol.

Methods

We subjected ten acute ischemic stroke patients with admission hyperglycemia (glucose >7.0 mmol/l (126.0 mg/dl)) to continuous tube feeding and a computerized intensive protocol with insulin adjustments every 1–2 h. Two groups of regularly fed patients from a previous study with a similar design served as controls. These groups comprised hyperglycemic patients treated according to an intermediate protocol with insulin adjustments at standard intervals (N = 13), and normoglycemic controls treated according to standard care (N = 15). The primary outcome was the percentage of time within target (4.4–6.1 mmol/l (79.2–109.8 mg/dl)). Secondary outcome was the number of patients with hypoglycemic episodes (glucose <3.0 mmol/l (54.0 mg/dl)).

Results

Median time within target was 55% in the continuously fed intensive group compared to 19% in the regularly fed intermediate group, and 58% in normoglycemic controls. Hypoglycemic episodes occurred in 20% of patients in the continuously fed group—lowest glucose level 2.4 mmol/l (43.2 mg/dl). In contrast, in the regularly fed group, this was 31%—lowest glucose level 1.6 mmol/l (28.8 mg/dl).

Conclusions

TGC after acute ischemic stroke is feasible with continuous tube feeding and a computerized intensive treatment protocol. Although glycemic control is associated with hypoglycemia, no severe hypoglycemia occurred in the continuous tube feeding group.

Keywords

Acute ischemic strokeHyperglycemiaStroke unitTight glycemic control

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • N. D. Kruyt
    • 1
    • 2
  • G. J. Biessels
    • 2
  • T. M. Vriesendorp
    • 3
  • J. H. DeVries
    • 3
  • J. B. L. Hoekstra
    • 3
  • P. W. Elbers
    • 4
  • L. J. Kappelle
    • 2
  • P. Portegies
    • 5
  • M. Vermeulen
    • 1
  • Y. B. W. E. M. Roos
    • 1
  1. 1.Department of Neurology, Academic Medical CenterUniversity of AmsterdamAmsterdamthe Netherlands
  2. 2.Department of Neurology, Rudolf Magnus Institute for NeuroscienceUniversity Medical CenterUtrechtthe Netherlands
  3. 3.Department of Internal MedicineAcademic Medical CenterAmsterdamthe Netherlands
  4. 4.Department of Anesthesia, Intensive Care and Pain ManagementSt. Antonius HospitalNieuwegeinthe Netherlands
  5. 5.Department of NeurologyOnze Lieve Vrouwen GasthuisAmsterdamthe Netherlands