Conventional Weaning Parameters do not Predict Extubation Failure in Neurocritical Care Patients
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Predicting extubation failure (EF) is one of the most challenging aspects of critical care medicine. The literature on EF in neurocritical care patients is very scarce. We sought to determine the ability of traditional weaning parameters to predict EF in neurocritical patients.
This is a retrospective observational study performed at a tertiary level, academic, Neurological Intensive Care Unit (NCCU). We included all adult patients intubated for neurological reasons in whom an attempt to perform extubation was performed. We compared traditional weaning parameters between patients who failed extubation and those successfully extubated. Fishers exact test was used for categorical variables and t-test for continuous variables. Weaning parameters were analyzed as categorical variables and when appropriate as continuous. We incorporated a coma scale (Four Score) in an attempt to determine if neurologic dysfunction could account for EF.
The study sample compromised 62 patients undergoing extubation trial. None of the individual weaning parameters predicted EF: rapid shallow breathing index (P = 0.62), minute ventilation (P = 0.7479), respiratory rate (P = 1.0), negative inspiratory force (P = 0.62), tidal volume, and PaO2/FIO2 ratio (P = 1.0). There was no significant difference in Four Scale score between EF and successfully extubated patients (0.44, proportions of the mean, t-test). There was no combination of weaning parameters that allowed prediction of EF. All patients had at least three normal weaning parameters, but there was no combination of parameters that accurately predicted EF. Overall, weaning parameters had better specificity than sensitivity for predicting EF.
In this sample of neurocritical care patients undergoing extubation trial, traditional weaning parameters do not predict extubation failure.
- Epstein SK. Predicting extubation failure. Chest. 2001;120:1061–3. doi:10.1378/chest.120.4.1061. CrossRef
- Tanios MA, Nevins ML, Hendra KP, et al. A randomized, controlled trial of the role of weaning predictors in clinical decision making. Crit Care Med. 2006;34:2530–5. doi:10.1097/01.CCM.0000236546.98861.25. CrossRef
- Epstein SK. Extubation failure: an outcome to be avoided. Crit Care. 2004;8:310–2. doi:10.1186/cc2927. CrossRef
- Coplin WM, Pierson DJ, Cooley KD, et al. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000;161:1530–6.
- Koutsoukou A, Perraki H, Raftopoulou A, et al. Respiratory mechanics in brain-injured patients. Intensive Care Med. 2006;32:1947–54. doi:10.1007/s00134-006-0406-0. CrossRef
- Wijdicks EF, Bamlet WR, Maramattom BV, et al. Validation of a new coma scale: the FOUR score. Ann Neurol. 2005;58(4):585–93. doi:10.1002/ana.20611. CrossRef
- Frutos-Vivar F, Ferguson N, Esteban A, et al. Risk factors for extubation failure in patients following a successful spontaneous breathing trial. Chest. 2006;130:1664–71. doi:10.1378/chest.130.6.1664. CrossRef
- Navalesi P, Frigerio P, Moretti M, et al. Rate of reintubation in mechanically ventilated neurosurgical and neurologic patients: evaluation of a systematic approach to weaning and extubation. Crit Care Med. 2008;36:2986–92. doi:10.1097/CCM.0b013e31818b35f2. CrossRef
- Vallverdu I, Calaf N, Subirana M, et al. Clinical characteristics, respiratory functional parameters, and outcome of a two-hour T-piece trial in patients weaning from mechanical ventilation. Am J Respir Crit Care Med. 1998;158:1855–62.
- Conventional Weaning Parameters do not Predict Extubation Failure in Neurocritical Care Patients
Volume 10, Issue 3 , pp 269-273
- Cover Date
- Print ISSN
- Online ISSN
- Humana Press Inc
- Additional Links
- Industry Sectors
- Author Affiliations
- 1. Department of Pulmonary and Critical Care Medicine Medical, University of South Carolina, Charleston, SC, USA
- 2. Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA
- 3. Department of Neurology, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC, USA