Neurocritical Care

, Volume 9, Issue 1, pp 118–121

Recurrent Takotsubo Cardiomyopathy Triggered by Convulsive Status Epilepticus

Authors

    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Fabrice Bruneel
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Ludovic Dalle
    • Service des UrgencesHôpital André Mignot
  • Corinne Appere-de-Vecchi
    • Service de Réanimation PolyvalenteCentre Hospitalier de Poissy
  • Jean Louis Georges
    • Service de cardiologieHôpital André Mignot
  • Nathalie Abbosh
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Matthieu Henry-Lagarrigue
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Laure Revault D’Allonnes
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Hager Ben Mokhtar
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Juliette Audibert
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Pierre Guezennec
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Gilles Troche
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
  • Jean Pierre Bedos
    • Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de Versailles
Practical Pearl

DOI: 10.1007/s12028-008-9107-6

Cite this article as:
Legriel, S., Bruneel, F., Dalle, L. et al. Neurocrit Care (2008) 9: 118. doi:10.1007/s12028-008-9107-6

Abstract

Introduction

Takotsubo cardiomyopathy can complicate several conditions including neurological emergencies. A few recurrent cases associated with seizures have been reported, but none of the patients had status epilepticus. The pathophysiology of takotsubo syndrome, although debated, may involve stunning of the myocardium by a catecholamine storm triggered by stress. Patients with epilepsy may be at increased risk for takotsubo syndrome, which may occur repeatedly.

Methods

We report on a postmenopausal woman with symptomatic epilepsy who experienced recurrent takotsubo cardiomyopathy triggered by convulsive status epilepticus. Brief seizures were not associated with takotsubo syndrome. The relevant literature was reviewed.

Results

Over a 1-year period, she experienced two episodes of convulsive status epilepticus with complete neurological recovery after treatment. Echocardiography showed latero-septo-apical hypokinesia and apical ballooning. The cardiac abnormalities resolved fully and she recovered her baseline level of self-sufficiency. During the same period, she experienced several brief seizures, with no cardiac manifestations.

Conclusion

The occurrence of takotsubo cardiomyopathy in association with convulsive status epilepticus, but not with brief seizures, supports neurogenically mediated myocardial stunning related to direct toxicity of endogenous catecholamines. Neuro-intensivists must be aware of this potentially fatal but fully reversible cardiac complication, which may be among the causes of death in patients with status epilepticus.

Keywords

Status epilepticusTakotsubo cardiomyopathyIntensive care unitCatecholaminesSeizures

Copyright information

© Humana Press Inc. 2008