Neurocritical Care

, Volume 8, Issue 3, pp 430–433

Baclofen and Gamma-Hydroxybutyrate Withdrawal

Authors

  • Jennifer L. LeTourneau
    • Division of Pulmonary & Critical Care Medicine and Center for Intensive Care Research, Department of MedicineOregon Health & Science University
  • Daniel S. Hagg
    • Division of Pulmonary & Critical Care Medicine and Center for Intensive Care Research, Department of MedicineOregon Health & Science University
    • Division of Pulmonary & Critical Care Medicine and Center for Intensive Care Research, Department of MedicineOregon Health & Science University
Article

DOI: 10.1007/s12028-008-9062-2

Cite this article as:
LeTourneau, J.L., Hagg, D.S. & Smith, S.M. Neurocrit Care (2008) 8: 430. doi:10.1007/s12028-008-9062-2

Abstract

Introduction

Benzodiazepine treatment of life-threatening gamma-hydroxybutyrate (GHB) withdrawal is frequently unsatisfactory. Animal studies suggest strongly that treatment with GABAB agonists, such as baclofen, will be a more effective strategy.

Methods

A case report from the medical intensive care unit (ICU) of the university tertiary care hospital.

Results

A 61-year-old woman was admitted to the medical ICU for severe withdrawal symptoms from chronic GHB use. This manifested as delirium, tremor, and seizures despite only small decreases in GHB dose and treatment with benzodiazepines. The addition of baclofen allowed the rapid sequential decreases in the GHB dose without seizure or delirium and resulted in long-term improvement of her tremor.

Conclusions

Baclofen, a GABAB agonist, may be a useful agent in the treatment of severe GHB withdrawal.

Keywords

Gamma-hydroxybutyrate dependenceBaclofenIntention tremor

List of Abbreviations

g

Grams

GABA

Gamma-aminobutyric acid

GHB

Gamma-hydroxybutyrate

h

Hours

ICU

Intensive care unit

mg

Milligrams

Copyright information

© Humana Press Inc. 2008