Glaucoma: recent advances in the involvement of autoimmunity

  • Maria Ida Rizzo
  • Antonio Greco
  • Armando De Virgilio
  • Andrea Gallo
  • Luciano Taverniti
  • Massimo Fusconi
  • Michela Conte
  • Giulio Pagliuca
  • Rosaria Turchetta
  • Marco de Vincentiis
Therapeutic Aspects in Autoimmunity

DOI: 10.1007/s12026-016-8837-3

Cite this article as:
Rizzo, M.I., Greco, A., De Virgilio, A. et al. Immunol Res (2016). doi:10.1007/s12026-016-8837-3

Abstract

Glaucomatous optic neuropathy is the most commonly acquired optic neuropathy encountered in clinical practice. It is the second leading cause of blindness globally, after cataracts, but it presents a greater public health challenge than cataracts, because the blindness it causes is irreversible. It has pathogenesis still largely unknown and no established cure. Alterations in serum antibody profiles, upregulation, and downregulation have been described, but it still remains elusive if the autoantibodies seen in glaucoma are an epiphenomenon or causative. Hypertension, diabetes, and hearing disorders also are associated. This review is a glaucoma update with focus about the recent advances in the last 15 years.

Keywords

Glaucoma Glaucomatous optic neuropathy Open-angle glaucoma Angle-closure glaucoma Normal-tension glaucoma Autoimmunity 

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Maria Ida Rizzo
    • 1
    • 2
  • Antonio Greco
    • 2
  • Armando De Virgilio
    • 1
    • 2
  • Andrea Gallo
    • 3
  • Luciano Taverniti
    • 4
  • Massimo Fusconi
    • 1
  • Michela Conte
    • 1
  • Giulio Pagliuca
    • 3
  • Rosaria Turchetta
    • 1
  • Marco de Vincentiis
    • 1
  1. 1.ENT Section, Department Organs of SenseUniversity of Rome “La Sapienza”RomeItaly
  2. 2.Department of Surgical ScienceUniversity of Rome “La Sapienza”RomeItaly
  3. 3.Otorhinolaryngology Section, Department of Medico-Surgical Sciences and Biotechnologies‘‘Sapienza’’ University of RomeLatinaItaly
  4. 4.Ophthalmology Section, Department Organs of SenseUniversity of Rome “La Sapienza”RomeItaly