Immunologic Research

, Volume 59, Issue 1, pp 12–22

Toll-like receptors and B cells: functions and mechanisms

Authors

  • Claire M. Buchta
    • Graduate Program in ImmunologyUniversity of Iowa
    • Graduate Program in ImmunologyUniversity of Iowa
    • Department of MicrobiologyUniversity of Iowa
    • Department of Internal MedicineUniversity of Iowa
    • Iowa City Veterans Affairs Medical Center
IMMUNOLOGY AT THE UNIVERSITY OF IOWA

DOI: 10.1007/s12026-014-8523-2

Cite this article as:
Buchta, C.M. & Bishop, G.A. Immunol Res (2014) 59: 12. doi:10.1007/s12026-014-8523-2

Abstract

Numerous reports have described Toll-like receptor (TLR) functions in myeloid cells such as dendritic cells (DCs) and macrophages, but relatively fewer studies have examined TLR responses in B lymphocytes. B cells express a wide variety of TLRs and are highly activated after TLR ligation, leading to enhancements in B cell survival, surface molecule expression, cytokine and antibody production, and antigen presentation. During an immune response, B cells can receive signals through TLRs as well as the B cell antigen receptor (BCR) and/or CD40. TLR ligation synergizes with signals through these receptors and augments both innate and adaptive immune functions of B lymphocytes. Additionally, targeting B cell TLRs may provide new therapies against certain types of cancer as well as autoimmune diseases. Here, we summarize TLR expression and contributions to both normal and pathogenic functions in mouse and human B cells.

Keywords

B lymphocytesToll-like receptorsAntibody productionImmunotherapy

Copyright information

© Springer Science+Business Media New York 2014