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ImmPort: disseminating data to the public for the future of immunology

  • IMMUNOLOGY AT STANFORD UNIVERSITY
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Abstract

The immunology database and analysis portal (ImmPort) system is the archival repository and dissemination vehicle for clinical and molecular datasets created by research consortia funded by the National Institute of Allergy and Infectious Diseases Division of Allergy, Immunology, and Transplantation. With nearly 100 datasets now publicly available and hundreds of downloads per month, ImmPort is an important source for raw data and protocols from clinical trials, mechanistic studies, and novel methods for cellular and molecular measurements. To facilitate data transfer, templates for data representation and standard operating procedures have also been created and are also publicly available. ImmPort facilitates transparency and reproducibility in immunology research, serves as an important resource for education, and enables newly generated hypotheses and data-driven science.

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References

  1. Qian Y, Wei C, Eun-Hyung Lee F, Campbell J, Halliley J, Lee JA, et al. Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data. Cytometry B Clin Cytom. 2010;78(Suppl 1):S69–82. doi:10.1002/cyto.b.20554.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, et al. A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant. 2012;12(10):2710–8. doi:10.1111/j.1600-6143.2012.04253.x.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Benfield MR, Bartosh S, Ikle D, Warshaw B, Bridges N, Morrison Y, et al. A randomized double-blind, placebo controlled trial of steroid withdrawal after pediatric renal transplantation. Am J Transplant. 2010;10(1):81–8. doi:10.1111/j.1600-6143.2009.02767.x.

    Article  CAS  PubMed  Google Scholar 

  4. De Serres SA, Mfarrej BG, Magee CN, Benitez F, Ashoor I, Sayegh MH, et al. Immune profile of pediatric renal transplant recipients following alemtuzumab induction. J Am Soc Nephrol. 2012;23(1):174–82. doi:10.1681/ASN.2011040360.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Harmon W, Meyers K, Ingelfinger J, McDonald R, McIntosh M, Ho M, et al. Safety and efficacy of a calcineurin inhibitor avoidance regimen in pediatric renal transplantation. J Am Soc Nephrol. 2006;17(6):1735–45. doi:10.1681/ASN.2006010049.

    Article  CAS  PubMed  Google Scholar 

  6. Hoerning A, Koss K, Datta D, Boneschansker L, Jones CN, Wong IY, et al. Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. Eur J Immunol. 2011;41(8):2291–302. doi:10.1002/eji.201041095.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. McDonald RA, Smith JM, Ho M, Lindblad R, Ikle D, Grimm P, et al. Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids. Am J Transplant. 2008;8(5):984–9. doi:10.1111/j.1600-6143.2008.02167.x.

    Article  CAS  PubMed  Google Scholar 

  8. Casale TB, Busse WW, Kline JN, Ballas ZK, Moss MH, Townley RG, et al. Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis. J Allergy Clin Immunol. 2006;117(1):134–40. doi:10.1016/j.jaci.2005.09.036.

    Article  CAS  PubMed  Google Scholar 

  9. Klunker S, Saggar LR, Seyfert-Margolis V, Asare AL, Casale TB, Durham SR, et al. Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: inhibition of IgE-facilitated allergen binding. J Allergy Clin Immunol. 2007;120(3):688–95. doi:10.1016/j.jaci.2007.05.034.

    Article  CAS  PubMed  Google Scholar 

  10. Newell EW, Sigel N, Bendall SC, Nolan GP, Davis MM. Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8(+) T cell phenotypes (vol 36, pg 142, 2012). Immunity. 2013;38(1):198–9. doi:10.1016/j.immuni.2012.12.002.

    Article  CAS  Google Scholar 

  11. Horowitz A, Strauss-Albee DM, Leipold M, Kubo J, Nemat-Gorgani N, Dogan OC, et al. Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med. 2013;5(208):208ra145. doi:10.1126/scitranslmed.3006702.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Stone JH, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med. 2010;363(3):221–32. doi:10.1056/NEJMoa0909905.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Holdren JP. Increasing access to the results of federally funded scientific research. Executive Office of the President, Washington, DC. 2013. http://www.whitehouse.gov/sites/default/files/microsites/ostp/ostp_public_access_memo_2013.pdf. Accessed Feb 22, 2013.

  14. Shen-Orr SS, Goldberger O, Garten Y, Rosenberg-Hasson Y, Lovelace PA, Hirschberg DL et al. Towards a cytokine-cell interaction knowledgebase of the adaptive immune system. Pac Symp Biocomput. 2009. http://www.ncbi.nlm.nih.gov/pubmed/?term=19209721.

  15. Piwowar HA, Vision TJ. Data reuse and the open data citation advantage. Peer J. 2013;1:e175. doi:10.7717/peerj.175.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Begley CG, Ellis LM. Drug development: raise standards for preclinical cancer research. Nature. 2012;483(7391):531–3. doi:10.1038/483531a.

    Article  CAS  PubMed  Google Scholar 

  17. Ioannidis JP, Allison DB, Ball CA, Coulibaly I, Cui X, Culhane AC, et al. Repeatability of published microarray gene expression analyses. Nat Genet. 2009;41(2):149–55. doi:10.1038/ng.295.

    Article  CAS  PubMed  Google Scholar 

  18. Micheel C, Nass SJ, Omenn GS, Institute of Medicine (U.S.). Committee on the review of omics-based tests for predicting patient outcomes in clinical trials. Evolution of translational omics: lessons learned and the path forward. Washington, D.C.: National Academies Press; 2012.

  19. Chen R, Sigdel TK, Li L, Kambham N, Dudley JT, Hsieh SC et al. Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol. 2010;6(9). doi:10.1371/journal.pcbi.1000940.

  20. Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, et al. Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A. 2012;109(18):7049–54. doi:10.1073/pnas.1114513109.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Roberts SA, Lawrence MS, Klimczak LJ, Grimm SA, Fargo D, Stojanov P, et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet. 2013;45(9):970–6. doi:10.1038/ng.2702.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, et al. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med. 2011;3(96):96ra77. doi:10.1126/scitranslmed.3001318.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, et al. Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med. 2011;3(96):96–976. doi:10.1126/scitranslmed.3002648.

    Article  Google Scholar 

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Acknowledgments

This work was supported in part by the National Institute of Allergy and Infectious Diseases (Bioinformatics Support Contract HHSN272201200028C). The authors thank Ashley Xia and Quan Chen at the National Institute of Allergy and Infectious Diseases for their oversight of the program. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Correspondence to Atul J. Butte.

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Bhattacharya, S., Andorf, S., Gomes, L. et al. ImmPort: disseminating data to the public for the future of immunology. Immunol Res 58, 234–239 (2014). https://doi.org/10.1007/s12026-014-8516-1

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  • DOI: https://doi.org/10.1007/s12026-014-8516-1

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