Immunologic Research

, Volume 58, Issue 2, pp 186–192

Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation

  • S. M. Ruppert
  • T. R. Hawn
  • A. Arrigoni
  • T. N. Wight
  • P. L. Bollyky
IMMUNOLOGY AT STANFORD UNIVERSITY

DOI: 10.1007/s12026-014-8495-2

Cite this article as:
Ruppert, S.M., Hawn, T.R., Arrigoni, A. et al. Immunol Res (2014) 58: 186. doi:10.1007/s12026-014-8495-2

Abstract

The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue catabolism and promotes inflammation via effects on Toll-like receptor signaling. Conversely, high-molecular weight HA is prevalent in uninjured tissues and is anti-inflammatory. We propose that the ability of high-molecular weight but not low-molecular weight HA to cross-link CD44 functions as a novel form of pattern recognition that recognizes intact tissues and communicates “tissue integrity signals” that promote resolution of local immune responses.

Keywords

HyaluronanDanger signalsDAMPIntegrity signalCD44ECM

Abbreviations

HMW-HA

High-molecular weight hyaluronan

LMW-HA

Low-molecular weight hyaluronan

HA

Hyaluronan

PAMPs

Pathogen-associated molecular patterns

DAMPs

Damage-associated molecular patterns

TLR

Toll-like receptor

APC

Antigen-presenting cell

DC

Dendritic cell

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • S. M. Ruppert
    • 1
  • T. R. Hawn
    • 2
  • A. Arrigoni
    • 1
  • T. N. Wight
    • 3
  • P. L. Bollyky
    • 1
  1. 1.Division of Infectious DiseasesStanford University School of MedicineStanfordUSA
  2. 2.Division of Allergy and Infectious DiseasesUniversity of Washington Medical CenterSeattleUSA
  3. 3.Matrix Biology DivisionBenaroya Research InstituteSeattleUSA