Immunologic Research

, Volume 58, Issue 2, pp 186–192

Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation

  • S. M. Ruppert
  • T. R. Hawn
  • A. Arrigoni
  • T. N. Wight
  • P. L. Bollyky
IMMUNOLOGY AT STANFORD UNIVERSITY

DOI: 10.1007/s12026-014-8495-2

Cite this article as:
Ruppert, S.M., Hawn, T.R., Arrigoni, A. et al. Immunol Res (2014) 58: 186. doi:10.1007/s12026-014-8495-2

Abstract

The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue catabolism and promotes inflammation via effects on Toll-like receptor signaling. Conversely, high-molecular weight HA is prevalent in uninjured tissues and is anti-inflammatory. We propose that the ability of high-molecular weight but not low-molecular weight HA to cross-link CD44 functions as a novel form of pattern recognition that recognizes intact tissues and communicates “tissue integrity signals” that promote resolution of local immune responses.

Keywords

Hyaluronan Danger signals DAMP Integrity signal CD44 ECM 

Abbreviations

HMW-HA

High-molecular weight hyaluronan

LMW-HA

Low-molecular weight hyaluronan

HA

Hyaluronan

PAMPs

Pathogen-associated molecular patterns

DAMPs

Damage-associated molecular patterns

TLR

Toll-like receptor

APC

Antigen-presenting cell

DC

Dendritic cell

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • S. M. Ruppert
    • 1
  • T. R. Hawn
    • 2
  • A. Arrigoni
    • 1
  • T. N. Wight
    • 3
  • P. L. Bollyky
    • 1
  1. 1.Division of Infectious DiseasesStanford University School of MedicineStanfordUSA
  2. 2.Division of Allergy and Infectious DiseasesUniversity of Washington Medical CenterSeattleUSA
  3. 3.Matrix Biology DivisionBenaroya Research InstituteSeattleUSA

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