Immunologic Research

, Volume 57, Issue 1, pp 159–165

Molecular studies and therapeutic targeting of Kaposi’s sarcoma herpesvirus (KSHV/HHV-8) oncogenesis

Authors

    • Department of Microbiology and Immunology, Graduate Program in Microbiology and Immunology, Miami Center for AIDS Research and Viral Oncology Program, Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of Medicine
  • Lucas E. Cavallin
    • Department of Microbiology and Immunology, Graduate Program in Microbiology and Immunology, Miami Center for AIDS Research and Viral Oncology Program, Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of Medicine
  • Brittany M. Ashlock
    • Department of Microbiology and Immunology, Graduate Program in Microbiology and Immunology, Miami Center for AIDS Research and Viral Oncology Program, Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of Medicine
  • Howard J. Leung
    • Department of Microbiology and Immunology, Graduate Program in Microbiology and Immunology, Miami Center for AIDS Research and Viral Oncology Program, Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of Medicine
  • Qi Ma
    • Department of Microbiology and Immunology, Graduate Program in Microbiology and Immunology, Miami Center for AIDS Research and Viral Oncology Program, Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of Medicine
  • Pascal J. Goldschmidt-Clermont
    • Department of Microbiology and Immunology, Graduate Program in Microbiology and Immunology, Miami Center for AIDS Research and Viral Oncology Program, Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of Medicine
Immunology & Microbiology in Miami

DOI: 10.1007/s12026-013-8458-z

Cite this article as:
Mesri, E.A., Cavallin, L.E., Ashlock, B.M. et al. Immunol Res (2013) 57: 159. doi:10.1007/s12026-013-8458-z

Abstract

Kaposi’s sarcoma herpesvirus or human herpesvirus-8 (KSHV/HHV-8) is the etiological agent of Kaposi’s sarcoma (KS), an AIDS-defining angioproliferative neoplasm that continues to be a major global health problem and, of primary effusion lymphoma (PEL), a rare incurable B-cell lymphoma. This review describes the research from our laboratory and its collaborators to uncover molecular mechanisms of viral oncogenesis in order to develop new pathogenesis-based therapies to the KSHV-induced AIDS malignancies KS and PEL. They include the discovery of the viral angiogenic oncogene G protein-coupled receptor (vGPCR), the development of mouse models of KSHV and oxidative stress-induced KS, the identification of the role of Rac1-induced ROS in viral oncogenesis of KS and the development of novel therapeutic approaches able to target both latent and lytic oncogenic KSHV infection.

Keywords

AIDS-associated malignanciesTargeted therapiesAntiviralsHuman herpesvirus-8AngiogenesisAnimal models of cancer

Copyright information

© Springer Science+Business Media New York 2013