Immunologic Research

, Volume 57, Issue 1, pp 210–221

Transdisciplinary approach to restore pancreatic islet function

  • Carmen Fotino
  • R. Damaris Molano
  • Camillo Ricordi
  • Antonello Pileggi
Immunology & Microbiology in Miami

DOI: 10.1007/s12026-013-8437-4

Cite this article as:
Fotino, C., Molano, R.D., Ricordi, C. et al. Immunol Res (2013) 57: 210. doi:10.1007/s12026-013-8437-4

Abstract

The focus of our research is on islet immunobiology. We are exploring novel strategies that could be of assistance in the treatment and prevention of type 1 diabetes, as well as in the restoration of metabolic control via transplantation of insulin producing cells (i.e., islet cells). The multiple facets of diabetes and β-cell replacement encompass different complementary disciplines, such as immunology, cell biology, pharmacology, and bioengineering, among others. Through their interaction and integration, a transdisciplinary dimension is needed in order to address and overcome all aspects of the complex puzzle toward a successful clinical translation of a biological cure for diabetes.

Keywords

Islet transplantationAutoimmunityRejectionEngraftmentInflammationInnate immunityBioengineeringImplantable deviceDiabetesType 1 diabetesDiabetes mellitusCell transplantationCellular therapiesTransplant microenvironmentImagingHyperbaric oxygen therapyATPPurinergic receptorsP2X7CD39CD73Adenosine (Ado)Beta cellImmunotherapyMetabolic controlNoninvasive imagingBioluminiscenceConfocal microscopyLive imaging

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Carmen Fotino
    • 1
  • R. Damaris Molano
    • 1
  • Camillo Ricordi
    • 1
    • 2
    • 3
    • 4
    • 5
  • Antonello Pileggi
    • 1
    • 2
    • 3
    • 4
  1. 1.Cell Transplant Center, Diabetes Research InstituteUniversity of MiamiMiamiUSA
  2. 2.DeWitt-Daughtry Department of SurgeryUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Department of Microbiology and ImmunologyUniversity of Miami Miller School of MedicineMiamiUSA
  4. 4.Department of Biomedical EngineeringUniversity of MiamiMiamiUSA
  5. 5.Department of MedicineUniversity of Miami Miller School of MedicineMiamiUSA