Immunologic Research

, Volume 52, Issue 1, pp 127–132

Inflammatory and immune mechanisms in contact hypersensitivity (CHS) in rats

Immunology in Serbia

DOI: 10.1007/s12026-012-8277-7

Cite this article as:
Popov, A., Mirkov, I. & Kataranovski, M. Immunol Res (2012) 52: 127. doi:10.1007/s12026-012-8277-7


Contact hypersensitivity (CHS) is a T-cell-mediated skin inflammatory reaction to cutaneous exposure to small sensitizing chemicals, haptens. Majority of CHS studies were conducted in mice and there is paucity of data in other experimental animals. In this review, after a brief survey of murine CHS, hitherto known characteristics of CHS in rats were presented including inflammatory and immune mechanisms of both sensitization and elicitation phases. Survey of literature of rat CHS is presented, with our data concerning the importance of genetic background both in the induction and in the expression of reaction to dinitrochlorobenzene. The knowledge of CHS in rats, preferred animal in immunopharmacological studies, might help development of immunomodulatory intervention in contact allergy.


Contact hypersensitivity (CHS)RatsDinitrochlorobenzene (DNCB)Ear swelling responseDraining lymph node responsePeripheral blood granulocytes

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of EcologyInstitute for Biological Research “Sinisa Stankovic,” University of BelgradeBelgradeSerbia
  2. 2.Faculty of Biology, Institute of Physiology and BiochemistryUniversity of BelgradeBelgradeSerbia