Immunologic Research

, Volume 53, Issue 1, pp 162–167

Severe drug eruptions revisited

Singapore Immunology Network

DOI: 10.1007/s12026-012-8271-0

Cite this article as:
Calbo, S. Immunol Res (2012) 53: 162. doi:10.1007/s12026-012-8271-0

Abstract

Genetic and non-genetic factors can alter the action of a medicinal drug, resulting in a wide range of responses in different individuals. Among the many potential side effects of therapies, a drug eruption is an adverse drug reaction in the skin. Genetic associations between HLA haplotype and drug eruption have been reported, and immune responses against latent herpesvirus have also been implicated in some forms of this syndrome. We believe that it is essential to understand the immune mechanisms by which some drugs induce hypersensitivity so that we can better target these pathways to limit drug side effects. The identification of patient risk factors for drug eruptions will allow the rational design of novel immunotherapies for these life-threatening reactions, and the development of alternative interventions for high-risk patients.

Keywords

Drug hypersensitivityAdverse drug reactionsDrug reaction with eosinophilia and systemic symptoms (DRESS)Stevens–Johnson Syndrome (SJS)The toxic epidermal necrolysis (TEN)Lyell’s syndromeHerpesvirusEpstein–Barr virusHuman herpesvirus 6

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)BiopolisSingaporeSingapore