Immunologic Research

, Volume 50, Issue 2, pp 181–187

IL-17 signaling in host defense against Candida albicans

  • Sarah L. Gaffen
  • Nydiaris Hernández-Santos
  • Alanna C. Peterson
UNIVERSITY OF PITTSBURGH IMMUNOLOGY 2011

DOI: 10.1007/s12026-011-8226-x

Cite this article as:
Gaffen, S.L., Hernández-Santos, N. & Peterson, A.C. Immunol Res (2011) 50: 181. doi:10.1007/s12026-011-8226-x

Abstract

The discovery of the Th17 lineage in 2005 triggered a major change in how immunity to infectious diseases is viewed. Fungal infections, in particular, have long been a relatively understudied area of investigation in terms of the host immune response. Candida albicans is a commensal yeast that colonizes mucosal sites and skin. In healthy individuals, it is non-pathogenic, but in conditions of immune deficiency, this organism can cause a variety of infections associated with considerable morbidity. Candida can also cause disseminated infections that have a high mortality rate and are a major clinical problem in hospital settings. Although immunity to Candida albicans was long considered to be mediated by Th1 cells, new data in both rodent models and in humans have revealed an essential role for the Th17 lineage, and in particular its signature cytokine IL-17.

Keywords

IL-17Th17Candida albicansFungal infectionsCytokine

Abbreviations

OPC

Oropharygeal candidiasis

CMC

Chronic mucocutaneous candidiaisis

HIES

Hyper-IgE Syndrome

APS-1

Autoimmune polyendocrine syndrome-1

AMP

Antimicrobial peptide

PRR

Pattern recognition receptor

AR

Autosomal recessive

LOF

Loss of function

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sarah L. Gaffen
    • 1
  • Nydiaris Hernández-Santos
    • 1
  • Alanna C. Peterson
    • 1
  1. 1.Division of Rheumatology and Clinical Immunology, Department of MedicineUniversity of PittsburghPittsburghUSA