Immunologic Research

, Volume 50, Issue 1, pp 39–48

T cell recognition of weak ligands: roles of signaling, receptor number, and affinity


DOI: 10.1007/s12026-011-8204-3

Cite this article as:
Edwards, L.J. & Evavold, B.D. Immunol Res (2011) 50: 39. doi:10.1007/s12026-011-8204-3


T cell recognition of antigen is a crucial aspect of the adaptive immune response. One of the most common means of pathogen immune evasion is mutation of T cell epitopes. T cell recognition of such ligands can result in a variety of outcomes including activation, apoptosis and anergy. The ability of a given T cell to respond to a specific peptide–MHC ligand is regulated by a number of factors, including the affinity, on- and off-rates and half-life of the TCR–peptide–MHC interaction. Interaction of T cells with low-potency ligands results in unique signaling patterns and requires engagement with a larger number of T cell receptors than agonist ligands. This review will address these aspects of T cell interaction with weak ligands and the ways in which these ligands have been utilized therapeutically.


T cellAltered peptide ligandsIntracellular signalingViral escapeAutoimmunity

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyEmory UniversityAtlantaUSA