Immunologic Research

, Volume 50, Issue 1, pp 22–38

Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions

  • Lisa Y. Lenertz
  • Monica L. Gavala
  • Yiming Zhu
  • Paul J. Bertics
Article

DOI: 10.1007/s12026-011-8203-4

Cite this article as:
Lenertz, L.Y., Gavala, M.L., Zhu, Y. et al. Immunol Res (2011) 50: 22. doi:10.1007/s12026-011-8203-4
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Abstract

The nucleotide receptor P2X7 is an attractive therapeutic target and potential biomarker for multiple inflammatory and neurologic disorders, and it is expressed in several immune, osteogenic, and neurologic cell types. Aside from its role in the nervous system, it is activated by ATP released at sites of tissue damage, inflammation, and infection. Ligand binding to P2X7 stimulates many cell responses, including calcium fluxes, MAPK activation, inflammatory mediator release, and apoptosis. Much work has centered on P2X7 action in cell death and mediator processing (e.g., pro-interleukin-1 cleavage by the inflammasome), but the contribution of P2X7 to transcriptional regulation is less well defined. This review will focus on the growing evidence for the importance of nucleotide-mediated gene expression, highlight several animal models, human genetic, and clinical studies that support P2X7 as a therapeutic target, and discuss the latest developments in anti-P2X7 clinical trials.

Keywords

Nucleotide receptorsP2X7Gene transcriptionFosBMacrophagesInflammation

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Lisa Y. Lenertz
    • 1
  • Monica L. Gavala
    • 1
  • Yiming Zhu
    • 1
  • Paul J. Bertics
    • 1
  1. 1.Department of Biomolecular Chemistry, School of Medicine and Public HealthThe University of Wisconsin-MadisonMadisonUSA