Immunologic Research

, Volume 47, Issue 1, pp 3–13

Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation

  • Zhou Zhu
  • Sun Young Oh
  • You Sook Cho
  • Li Zhang
  • Yoon-Keun Kim
  • Tao Zheng
Article

DOI: 10.1007/s12026-009-8134-5

Cite this article as:
Zhu, Z., Oh, S.Y., Cho, Y.S. et al. Immunol Res (2010) 47: 3. doi:10.1007/s12026-009-8134-5

Abstract

Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.

Keywords

PhosphataseMast cellsTh2 cytokinesAllergic inflammatory responseAllergyAsthma

Abbreviations

BMMC

Bone marrow-derived mast cells

FcεRI

High-affinity Fc receptor for IgE

SCF

Stem cell factor or c-Kit ligand

me

Motheaten

mev

Viable motheaten

LAT2

Linker for activation of T cells 2, also called NTAL or LAB

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Zhou Zhu
    • 1
  • Sun Young Oh
    • 1
  • You Sook Cho
    • 1
  • Li Zhang
    • 1
  • Yoon-Keun Kim
    • 1
  • Tao Zheng
    • 1
  1. 1.Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy CenterJohns Hopkins UniversityBaltimoreUSA