Immunologic Research

, 45:209

Unravelling the mechanisms of help for CD8+ T cell responses

Authors

    • David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, and Department of Microbiology and ImmunologyUniversity of Rochester Medical Center
  • Elizabeth B. Wilson
    • David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, and Department of Microbiology and ImmunologyUniversity of Rochester Medical Center
  • Fernando Ontiveros
    • David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, and Department of Microbiology and ImmunologyUniversity of Rochester Medical Center
  • Jyh-Chiang E. Wang
    • David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, and Department of Microbiology and ImmunologyUniversity of Rochester Medical Center
Article

DOI: 10.1007/s12026-009-8102-0

Cite this article as:
Livingstone, A.M., Wilson, E.B., Ontiveros, F. et al. Immunol Res (2009) 45: 209. doi:10.1007/s12026-009-8102-0

Abstract

CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of protective and therapeutic immunity. Understanding the mechanisms of help is thus essential for vaccine design, and for restoring protective immunity in immunosuppressed individuals. Our laboratory has developed an immunization protocol using peptide-pulsed dendritic cells to stimulate help-dependent primary, memory, and secondary CD8+ T cell responses. We have used gene-targeted and T cell receptor transgenic mice to identify two distinct pathways that generate help-dependent and help-independent CD8+ T cell responses, respectively, and are now starting to define the molecular mechanisms underlying these two pathways.

Keywords

CD8+ T cellCD4+ T cell helpDendritic cellsT cell memory

Copyright information

© Springer Science+Business Media, LLC 2009