Immunologic Research

, Volume 45, Issue 2, pp 195–208

Leukocyte integrins and their ligand interactions

Article

DOI: 10.1007/s12026-009-8101-1

Cite this article as:
Hyun, Y., Lefort, C.T. & Kim, M. Immunol Res (2009) 45: 195. doi:10.1007/s12026-009-8101-1

Abstract

Although critical for cell adhesion and migration during normal immune-mediated reactions, leukocyte integrins are also involved in the pathogenesis of diverse clinical conditions including autoimmune diseases and chronic inflammation. Leukocyte integrins therefore have been targets for anti-adhesive therapies to treat the inflammatory disorders. Recently, the therapeutic potential of integrin antagonists has been demonstrated in psoriasis and multiple sclerosis. However, current therapeutics broadly affect integrin functions and, thus, yield unfavorable side effects. This review discusses the major leukocyte integrins and the anti-adhesion strategies for treating immune diseases.

Keywords

IntegrinLFA-1Mac-1VLA-4

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and ImmunologyUniversity of RochesterRochesterUSA