Article

Immunologic Research

, 43:109

First online:

IRF8 regulates myeloid and B lymphoid lineage diversification

  • Hongsheng WangAffiliated withLaboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Email author 
  • , Herbert C. MorseIIIAffiliated withLaboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health

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Abstract

Interferon regulatory factor 8 (IRF8) is a member of the IRF family of transcription factors whose members play critical roles in interferon (IFN) signaling pathways governing the establishment of innate immune responses by myeloid and dendritic cells. IRF8 is also expressed in lymphoid cells and recent studies have documented its involvement in B cell lineage specification, immunoglobulin light chain gene rearrangement, the distribution of mature B cells into the marginal zone and follicular B cell compartment, and the transcriptional regulation of critical elements of the germinal center reaction. Here we review the contributions of IRF8 to B cell development from hematopoietic stem cells in the bone marrow and its place in the hierarchical regulatory network governing specification and commitment to the B cell fate.

Keywords

Hematopoietic stem cell Common lymphoid progenitor IRF8 PU.1 EBF PAX5 E2A Pre-pro-B Lineage B cell