Immunologic Research

, Volume 39, Issue 1, pp 185–193

The role of platelet CD154 in the modulation in adaptive immunity

  • Daniel L. Sprague
  • Jennifer M. Sowa
  • Bennett D. Elzey
  • Timothy L. Ratliff
Article

DOI: 10.1007/s12026-007-0074-3

Cite this article as:
Sprague, D.L., Sowa, J.M., Elzey, B.D. et al. Immunol Res (2007) 39: 185. doi:10.1007/s12026-007-0074-3

Abstract

Platelets’ primary role is hemostasis. However, a growing body of research has demonstrated that platelets are integral to the initiation of an inflammatory response and are potent effector cells of the innate immune response. Activated platelets express CD154, a molecule critical to adaptive immune responses, which has been implicated in platelet-mediated modulation of innate immune responses and inflammation. Recent studies utilizing CD154 knockout mice extend the role of platelet-derived CD154 to the modulation of adaptive immune response by enhancing antigen presentation, improving CD8+ T cell responses, and playing a critical function in T-dependent humoral immunity under physiological conditions. Together these data provide a basis for the expansion of the current paradigm of B cell activation and germinal center formation to include a role for platelets.

Keywords

Platelets CD154 B cells T cells Humoral immunity Immune regulation 

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Daniel L. Sprague
    • 1
    • 2
    • 3
  • Jennifer M. Sowa
    • 1
    • 4
  • Bennett D. Elzey
    • 1
  • Timothy L. Ratliff
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Department of UrologyUniversity of IowaIowa CityUSA
  2. 2.Medical Scientist Training ProgramUniversity of IowaIowa CityUSA
  3. 3.Department of MicrobiologyUniversity of IowaIowa CityUSA
  4. 4.Interdisciplinary Immunology ProgramUniversity of IowaIowa CityUSA
  5. 5.Holden Comprehensive Cancer CenterUniversity of IowaIowa CityUSA

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