, Volume 41, Issue 1, pp 34-44
Date: 04 Mar 2008

Graft-versus-host disease and immunosuppression

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Introduction

In the last four decades, allogeneic hematopoietic stem cell transplant (HSCT) has been established as a curative therapy for many otherwise fatal diseases. Since 1968, from the time of the first successful allogeneic bone marrow transplant in a child with severe combined immune deficiency disease [1], tremendous progress has been made in this field of medicine that now we have ventured from perfect molecular matched sibling donor HSCT to unrelated donor and haploidentical donor HSCT [26] with successful outcome of the procedure. The success of these procedures in the treatment of lethal diseases has given us the courage of performing allogeneic HSCT transplant in sub-lethal diseases such as thalassemia and sickle-cell anemia. However, the procedure of HSCT transplant is associated with some very serious and fatal complications such as acute organ toxicity, especially sinusoidal obstruction syndrome infections, graft-versus-host disease (GvHD), and immune deficiency.

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Presented at the First Robert A Good Society Symposium, St. Petersburg, FL 2006.