Endocrine Pathology

, Volume 22, Issue 2, pp 86–96

Differential Expression of a Set of Genes in Follicular and Classic Variants of Papillary Thyroid Carcinoma

  • Yusuf Ziya Igci
  • Ahmet Arslan
  • Ersin Akarsu
  • Suna Erkilic
  • Mehri Igci
  • Serdar Oztuzcu
  • Beyhan Cengiz
  • Bulent Gogebakan
  • Ecir Ali Cakmak
  • A. Tuncay Demiryurek
Article

DOI: 10.1007/s12022-011-9157-8

Cite this article as:
Igci, Y.Z., Arslan, A., Akarsu, E. et al. Endocr Pathol (2011) 22: 86. doi:10.1007/s12022-011-9157-8

Abstract

Fine-needle aspiration biopsy (FNA) is currently the best initial diagnostic test for evaluation of a thyroid nodule. FNA cytology cannot discriminate between benign and malignant thyroid nodules in up to 30% of thyroid nodules. Therefore, an adjunct to FNA is needed to clarify these lesions as benign or malignant. Using differential display-polymerase chain reaction method, the gene expression differences between follicular and classic variants of papillary thyroid carcinoma (PTC) and benign thyroid nodules were evaluated in a group of 42 patients. Computational gene function analyses via Cytoscape, FuncBASE, and GeneMANIA led us to a functional network of 17 genes in which a core sub-network of five genes coexists. Although the exact mechanisms underlying in thyroid cancer biogenesis are not currently known, our data suggest that the pattern of transformation from healthy cells to cancer cells of PTC is different in follicular variant than in classic variant.

Keywords

Papillary thyroid carcinomaFollicular variant of papillary thyroid carcinomaClassic variant of papillary thyroid carcinomaDifferential display–polymerase chain reactionGeneMANIA

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yusuf Ziya Igci
    • 1
  • Ahmet Arslan
    • 1
  • Ersin Akarsu
    • 2
  • Suna Erkilic
    • 3
  • Mehri Igci
    • 1
  • Serdar Oztuzcu
    • 1
  • Beyhan Cengiz
    • 4
  • Bulent Gogebakan
    • 1
  • Ecir Ali Cakmak
    • 1
  • A. Tuncay Demiryurek
    • 5
  1. 1.Department of Medical Biology, Faculty of MedicineUniversity of GaziantepGaziantepTurkey
  2. 2.Department of Endocrinology, Faculty of MedicineUniversity of GaziantepGaziantepTurkey
  3. 3.Department of Pathology, Faculty of MedicineUniversity of GaziantepGaziantepTurkey
  4. 4.Department of Physiology, Faculty of MedicineUniversity of GaziantepGaziantepTurkey
  5. 5.Department of Medical Pharmacology, Faculty of MedicineUniversity of GaziantepGaziantepTurkey