Endocrine Pathology

, Volume 14, Issue 3, pp 183–191

Controversies in papillary microcarcinoma of the thyroid

  • Monique Piersanti
  • Shereen Ezzat
  • Sylvia L. Asa
Review

DOI: 10.1007/s12022-003-0011-5

Cite this article as:
Piersanti, M., Ezzat, S. & Asa, S.L. Endocr Pathol (2003) 14: 183. doi:10.1007/s12022-003-0011-5

Abstract

Papillary thyroid carcinomas that are smaller than 1 cm are classified as papillary microcarcinomas (PMC). These lesions are frequently detected as incidental findings on autopsy or in surgical specimens. They are often multifocal. The relationship between PMC and clinical papillary thyroid carcinoma (PTC) is not clear. In patients with clinical thyroid cancer, PMC may represent intrathyroidal metastases; they may be the earliest form of future large lesions. These uncertainties raise questions about appropriate clinical management of patients with these lesions. Review of the literature substantiates the argument that clinically evident PTC may be distinctly different from solitary or multifocal PMC in terms of etiology and biologic behavior, supporting a conservative approach to management.

Key Words

Thyroid microcarcinoma papillary carcinoma ret/PTC 

Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  • Monique Piersanti
    • 1
  • Shereen Ezzat
    • 1
  • Sylvia L. Asa
    • 2
  1. 1.Department of Medicine, Mount Sinai Hospital andUniversity of TorontoTorontoCanada
  2. 2.Department of PathologyUniversity Health Network and University of Toronto, The Freeman Centre for Endocrine Oncology and The Ontario Cancer InstituteTorontoCanada

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