, Volume 9, Issue 2-3, pp 103-105
Date: 18 Dec 2010

Proof-editing is the Bottleneck Of 3D Neuron Reconstruction: The Problem and Solutions

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3D neuron reconstruction is a challenging problem. Although much effort has been made in automatic tracing individual neurons, not much attention has been given to proof-editing, which is the real bottleneck. In the following we suggest two possible solutions, (a) a high-speed manual proof-editor based on effective 3D WYSIWYG (“what you see is what you get”) techniques provided by combining the V3D system and other automatic error analyzers, and (b) a fully automatic proof-editor that also predicts the types of errors and the error bounds.

Past and ongoing efforts to reverse engineer a brain usually start by reconstructing, or tracing, neuron models from 3D microscopic images.

Peng H, Ruan Z, Long F, Simpson JH, Myers EW, (2010) "V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets," Nature Biotechnology, 28(4): 348-353.


Peng H, Ruan Z, Atasoy D, Sternson S, (2010) "Automatic reconstruction of 3D neuron structures using a graph-augme